- Title
- Synthesis and biological evaluation of bis-N2, N2′-(4-hydroxycoumarin-3-yl) ethylidene]-2, 3-dihydroxysuccinodihydrazides
- Creator
- Manyeruke, Meloddy H, Tshiwawa, Tendamudzimu, Hoppe, Heinrich C, Isaacs, Michelle, Seldon, Ronnett, Warner, Digby F, Krause, Rui W M, Kaye, Perry T
- Subject
- To be catalogued
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/193430
- Identifier
- vital:45331
- Identifier
- xlink:href="https://doi.org/10.1016/j.bmcl.2019.126911"
- Description
- A series of N2,N2′-bis[4-hydroxycoumarin-3-yl)ethylidene]-2,3-dihydroxysuccino-hydrazides, containing 4-hydroxycoumarin, hydrazine and tartaric acid moieties, have been prepared and examined for possible biological activity. Several of these compounds exhibit promising HIV-1 integrase inhibition (IC50 = 3.5 μM), and anti-T. brucei (32% viability) and anti-mycobacterial (Visual MIC90 = 15.63 μM) activity.
- Format
- computer, online resource, application/pdf, 1 online resource (4 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Bioorganic Medicinal Chemistry Letters, Manyeruke, M.H., Tshiwawa, T., Hoppe, H.C., Isaacs, M., Seldon, R., Warner, D.F., Krause, R.W. and Kaye, P.T., 2020. Synthesis and biological evaluation of bis-N2, N2′-(4-hydroxycoumarin-3-yl) ethylidene]-2, 3-dihydroxysuccinodihydrazides. Bioorganic and medicinal chemistry letters, 30(5), p.126911, Bioorganic Medicinal Chemistry Letters volume 30 number 5 p. 126911 2020 0960-894X
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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Collections
Tshiwawa, Tendamudzimu (Dr)
Krause, Rui Werner Maçedo (Prof)
Hoppe, Heinrich C (Prof)
Isaacs, Michelle (Mrs)
Kaye, Perry T (Distinguished Fellow Emeritus Professor)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | Synthesis and biological evaluation of bis-N2, N2′-(4-hydroxycoumarin-3-yl) ethylidene]-2, 3-dihydroxysuccinodihydrazides.pdf | 868 KB | Adobe Acrobat PDF | View Details |