- Title
- Green synthesis of zinc oxide nanoparticles using Solanum torvum (L) leaf extract and evaluation of the toxicological profile of the ZnO nanoparticles–hydrogel composite in Wistar albino rats
- Creator
- Ezealisiji, Kenneth E, Siwe-Noundou, Xavier, Maduelosi, Blessing, Nwachukwu, Nkemakolam, Krause, Rui W M
- Subject
- To be catalogued
- Date
- 2019
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/194015
- Identifier
- vital:45416
- Identifier
- xlink:href="https://doi.org/10.1007/s40089-018-0263-1"
- Description
- Current study reports a simple and one-pot synthesis of zinc oxide nanoparticles (ZnONPs) using an aqueous extract of Solanum torvum and evaluation of its toxicological profile (0.5% w/w and 1.0% w/w) in Wistar albino rats with respect to the biochemical index. The nanoparticles were characterized using ultraviolet–visible spectroscopy, transmission electron microscopy, Fourier transform infrared spectroscopy and X-ray diffraction technique. Dynamic light scattering (DLS) and zeta potential of synthesized nanoparticles were analyzed to know the average size and stability of particles. Synthesized nanoparticles were stable, discreet, and mostly spherical, and size of particles was within the nanometre range. Biochemical markers of hepatic and renal functions were measured. Zinc oxide nanoparticles significantly decreased serum uric acid level (p less than 0.001) in a dose-dependent manner, while the serum alkaline phosphatase level was increased at the two test doses. The level of alanine transaminase was increased after exposure for 28 days (p less than 0.05). This study concludes that biogenic zinc oxide nanoparticles-infused hydrogel applied dermatologically could affect hepatic and renal performance in rats, and there was an observed cumulative toxicological effect with time of exposure.
- Format
- computer, online resource, application/pdf, 1 online resource (9 pages), pdf
- Publisher
- SpringerLink
- Language
- English
- Relation
- International Nano Letters, Ezealisiji, K.M., Siwe-Noundou, X., Maduelosi, B., Nwachukwu, N. and Krause, R.W.M., 2019. Green synthesis of zinc oxide nanoparticles using Solanum torvum (L) leaf extract and evaluation of the toxicological profile of the ZnO nanoparticles–hydrogel composite in Wistar albino rats. International Nano Letters, 9(2), pp.99-107, International Nano Letters volume 9 number 2 p. 99 2019 2228-5326
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the SpringerLink Terms of Use Statement ( https://link.springer.com/termsandconditions)
- Rights
- Open Access
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Krause, Rui Werner Maçedo (Prof)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Green synthesis of zinc oxide nanoparticles using Solanum torvum (L).pdf | 1 MB | Adobe Acrobat PDF | View Details Download |