- Title
- Antiplasmodial Activity of the n-Hexane Extract from Pleurotus ostreatus (Jacq. ex. Fr) P. Kumm
- Creator
- Afieroho, Ozadheoghene E, Siwe-Noundou, Xavier, Onyia, Chiazor P, Festus, Osamuyi H, Chukwu, Elizabeth C, Adedokun, Olutayo M, Isaacs, Michelle, Hoppe, Heinrich C, Krause, Rui W M, Abo, Kio A
- Subject
- To be catalogued
- Date
- 2019
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/194981
- Identifier
- vital:45516
- Identifier
- xlink:href="https://doi.org/10.4274/tjps.18894"
- Description
- Objectives: Several mushrooms species have been reported to be nematophagous and antiprotozoan. This study reported the antiplasmodial and cytotoxic properties of the n-hexane extract from the edible mushroom Pleurotus ostreatus and the isolation of a sterol from the extract. Materials and Methods: Antiplasmodial and cytotoxicity assays were done in vitro using the plasmodium lactate dehydrogenase assay and human HeLa cervical cell lines, respectively. The structure of the isolated compound from the n-hexane extract was elucidated using spectroscopic techniques. Results: The n-hexane extract (yield: 0.93% w/w) showed dose dependent antiplasmodial activity with the trend in parasite inhibition of: chloroquine (IC50=0.016 μg/mL) > n-hexane extract (IC50=25.18 μg/mL). It also showed mild cytotoxicity (IC50>100 μg/mL; selectivity index >4) compared to the reference drug emetine (IC50=0.013 μg/mL). The known sterol, ergostan-5,7,22-trien-3-ol, was isolated and characterized from the extract. Conclusion: This study reporting for the first time the antiplasmodial activity of P. ostreatus revealed its nutraceutical potential in the management of malaria.
- Format
- computer, online resource, application/pdf, 1 online resource (6 pages), pdf
- Publisher
- Galenos Yayınevi
- Language
- English
- Relation
- Turkish Journal of Pharmaceutical Sciences, Afieroho, O.E., Noundou, X.S., Onyia, C.P., Festus, O.H., Chukwu, E.C., Adedokun, O.M., Isaacs, M., Hoppe, H.C. and Krause, R.W., 2019. Antiplasmodial Activity of the n-Hexane Extract from Pleurotus ostreatus (Jacq. ex. Fr) P. Kumm. Turkish Journal of Pharmaceutical Sciences, 16(1), p.37, Turkish Journal of Pharmaceutical Sciences volume 16 number 1 p. 37 2019 2148-6247
- Rights
- Publisher
- Rights
- This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 (CC BY-NC-ND) International License
- Rights
- Open Access
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Collections
Krause, Rui Werner Maçedo (Prof)
Hoppe, Heinrich C (Prof)
Isaacs, Michelle (Mrs)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
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| View Details | SOURCE1 | Antiplasmodial Activity of the n-Hexane Extract.pdf | 353 KB | Adobe Acrobat PDF | View Details |