- Title
- In vitro photoinactivation of S. aureus and photocatalytic degradation of tetracycline by novel phthalocyanine-graphene quantum dots nano-assemblies
- Creator
- Openda, Yolande Ikala, Mgidlana, Sithi, Nyokong, Tebello
- Subject
- To be catalogued
- Date
- 2022
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/229895
- Identifier
- vital:49721
- Identifier
- xlink:href="https://doi.org/10.1016/j.jlumin.2022.118863"
- Description
- A novel asymmetrical zinc (II) phthalocyanine (Pc) 4 bearing three dimethoxy groups and one carboxyl group was linked to glutathione capped graphene quantum dots (GQDs) by the reaction of carboxylic acid substituent on Pc 4 with the amino group on the GQDs. On the other side, the symmetrical Pc analog 3 was linked to the same nanoparticles through π-π interactions. The as-formed nano-photosensitizers were fully characterized by spectroscopic methods and their photophysicochemical properties were investigated as well. Photodynamic antimicrobial chemotherapy was performed on the planktonic cells of S. aureus strain. And the results show that these nano assemblies were able to completely inhibit the metabolic activity of the resistant bacteria strain S. aureus with a 10.26 log reduction in the viable count. Again, asymmetrical Pc showed higher photocatalytic activity compared to the symmetrical complex with higher kobs and fast initial rates for the former. The photocatalysis obeyed the Langmuir-Hinshelwood kinetic model. The target conjugates showed all the advantages of two different groups existing on a single entity.
- Format
- computer, online resource, application/pdf, 1 online resource (13 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Journal of Luminescence, Openda, Y.I., Mgidlana, S. and Nyokong, T., 2022. In vitro photoinactivation of S. aureus and photocatalytic degradation of tetracycline by novel phthalocyanine-graphene quantum dots nano-assemblies. Journal of Luminescence, p.118863, Journal of Luminescence p. 118863 2022 0022-2313
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | In vitro photoinactivation.pdf | 821 KB | Adobe Acrobat PDF | View Details Download |