- Title
- Photodynamic therapy characteristics of phthalocyanines in the presence of boron doped detonation nanodiamonds
- Creator
- Matshitse, Refilwe, Nwaji, Njemuwa, Managa, Muthimuni, Chen, Zhi-Long, Nyokong, Tebello
- Subject
- To be catalogued
- Date
- 2022
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/229921
- Identifier
- vital:49723
- Identifier
- xlink:href="https://doi.org/10.1016/j.pdpdt.2021.102705"
- Description
- The synthesis, photophysicochemical and photodynamic therapy (PDT) activities of benzothiazole substituted zinc phthalocyanine (Pc): 1 (asymmetrically substituted and composed of no charges), 2 (asymmetrically substituted and composed of three positive charges), and 3 (symmetrically substituted and composed of four positive charges), are presented. The triplet and singlet oxygen quantum yields were highest for complex 2 showing the importance of asymmetry and charge. The complexes are covalently and non-covalently linked to B doped detonation nanodiamonds (B@DNDs) to yield nanohybrids (B@DNDs-1, B@DNDs-2, B@DNDs-3). The presence of B@DNDs, asymmetry and positive charge resulted in improved PDT with the lowest cell viability being observed for B@DNDs-2 at 5%. The cell viability ranged from 5% to 7% for the nanohybrids compared to 19–26% for Pcs alone.
- Format
- computer, online resource, application/pdf, 1 online resource (11 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Photodiagnosis and Photodynamic Therapy, Matshitse, R., Nwaji, N., Managa, M., Chen, Z.L. and Nyokong, T., 2022. Photodynamic therapy characteristics of phthalocyanines in the presence of boron doped detonation nanodiamonds: Effect of symmetry and charge. Photodiagnosis and Photodynamic Therapy, 37, p.102705, Photodiagnosis and Photodynamic Therapy volume 37 p. 102705 2022 1572-1000
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | Photodynamic therapy characteristics of phthalocyanines.pdf | 866 KB | Adobe Acrobat PDF | View Details |