- Title
- Nanohybrid electrocatalyst based on cobalt phthalocyanine-carbon nanotube-reduced graphene oxide for ultrasensitive detection of glucose in human saliva
- Creator
- Adeniyi, Omotayo, Nwahara, Nnamdi, Mwanza, Daniel, Nyokong, Tebello, Mashazi, Philani N
- Subject
- To be catalogued
- Date
- 2021
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/231356
- Identifier
- vital:49880
- Identifier
- xlink:href="https://doi.org/10.1016/j.snb.2021.130723"
- Description
- The current diabetes management systems require collecting blood samples via an invasive and painful finger pricking leading to the formation of callus, scarring and loss of sensibility to patients due to continuous monitoring. Therefore, a non-invasive and painless method of determining glucose levels would be desirable to diabetes patients who need constant monitoring. Saliva glucose measurement is a non-invasive alternative for diabetes management. A highly sensitive, stable, and selective non-enzymatic electrochemical sensor that can accurately quantify saliva glucose is required. A single-walled carbon nanotube/reduced graphene oxide/cobalt phthalocyanines nanohybrid modified glassy carbon electrode (GCE-SWCNT/rGO/CoPc) has been fabricated for the non-enzymatic determination of glucose in human saliva. The SWCNT/rGO/CoPc was characterized using various spectroscopic, microscopic, and electrochemical techniques. The synergistic effect between SWCNT, rGO, and CoPc facilitated excellent electron transfer process that improved the sensor sensitivity. The GCE-SWCNT/rGO/CoPc sensor exhibited two linear responses in the 0.30 μM to 0.50 mM and 0.50–5.0 mM glucose concentration ranges, and the detection limit was 0.12 μM. The sensor had an excellent saliva glucose detection sensitivity of 992.4 μA·mM−1·cm−2 and high specificity for glucose in the presence of other coexisting analytes. In addition, it showed good storage stability, reusability, and a fast response time of about 1.2 s. The GCE-SWCNT/rGO/CoPc nanohybrid electrode showed excellent potential for developing accurate, non-invasive, and painless glucose sensing.
- Format
- computer, online resource, application/pdf, 1 online resource (13 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Sensors and Actuators B: Chemical, Adeniyi, O., Nwahara, N., Mwanza, D., Nyokong, T. and Mashazi, P., 2021. Nanohybrid electrocatalyst based on cobalt phthalocyanine-carbon nanotube-reduced graphene oxide for ultrasensitive detection of glucose in human saliva. Sensors and Actuators B: Chemical, 348, p.130723, Sensors and Actuators B: Chemical volume 348 p. 130723 2021 0925-4005
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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Mashazi, Philani N (Associate Prof)
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
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