Folic acid-modified phthalocyanine-nanozyme loaded liposomes for targeted photodynamic therapy

Nwahara, Nnamdi; Abrahams, Garth; Prinsloo, Earl

Title: Folic acid-modified phthalocyanine-nanozyme loaded liposomes for targeted photodynamic therapy
Creator: Nwahara, Nnamdi, Abrahams, Garth, Prinsloo, Earl, Nyokong, Tebello
Subject: To be catalogued
Date: 2021
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/231369
Identifier: vital:49881
Identifier: xlink:href="https://doi.org/10.1016/j.pdpdt.2021.102527"
Description: The hypoxic tumour microenvironment and poor spatiotemporal localization of photosensitizers are two significant obstacles that limit practical applications of photodynamic therapy. In response, a biocompatible, light-activatable liposome integrated with both a zinc phthalocyanine photodynamic component and Pt nanoparticles-decorated with MnO2 catalase-mimicking component are engineered. This multifunctional system was rationally designed using unsaturated phospholipids to achieve on-demand drug release following light irradiation. Specificity was achieved by folic acid functionalization resulting in folate-modified liposomes (FTLiposomes). We demonstrated its specific uptake by fluorescence imaging using folate receptor (FR) overexpressing HeLa and MCF-7 cells as in vitro models. This multifunctional liposome exhibits superior hypoxic anti-tumour effects and holds the potential to reduce side effects associated with untargeted therapy. Fluorescence of the constituent ZnPc and folate-receptor targeting could enable tracking and permit spatiotemporal regulation for improved cancer treatment.
Format: computer, online resource, application/pdf, 1 online resource (11 pages), pdf
Publisher: Elsevier
Language: English
Relation: Photodiagnosis and Photodynamic Therapy, Nwahara, N., Abrahams, G., Prinsloo, E. and Nyokong, T., 2021. Folic acid-modified phthalocyanine-nanozyme loaded liposomes for targeted photodynamic therapy. Photodiagnosis and Photodynamic Therapy, 36, p.102527, Photodiagnosis and Photodynamic Therapy volume 36 p. 102527 2021 1572-1000
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
Rights: Closed Access

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