- Title
- Physicochemical properties of water soluble unsymmetrical phthalocyanine-folic acid conjugates
- Creator
- Matlou, Gauta G, Kobayashi, Nagao, Kimura, Mutsumi, Nyokong, Tebello
- Subject
- To be catalogued
- Date
- 2018
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/233240
- Identifier
- vital:50071
- Identifier
- xlink:href="https://doi.org/10.1016/j.dyepig.2017.10.030"
- Description
- This work reports on the successful chemical linkage of folic acid (FA) to Zn mono carboxyphenoxy phthalocyanine (1) and Zn mono carboxyphenoxy tri–(tert–butyl) phthalocyanine (2). The amide bond linkage of FA to phthalocyanine (Pc) is achieved for the first time through the FA-NH2 and Pc-COOH and confirmed using FTIR, MS, elemental analysis and NMR. The linked conjugates were found to be water soluble compared to the physical mixtures of FA and Pc, which allowed for studies of singlet oxygen in water. The Pc-FA linked conjugates (1-FA and 2-FA) were found to be singlet oxygen generators with the following singlet oxygen quantum yields: 1-FA = 0.61 and 2-FA = 0.47 in DMSO and 1-FA = 0.17 and 2-FA = 0.12 in water.
- Format
- computer, online resource, application/pdf, 1 online resource (6 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Dyes and Pigments, Matlou, G.G., Kobayashi, N., Kimura, M. and Nyokong, T., 2018. Physicochemical properties of water soluble unsymmetrical phthalocyanine-folic acid conjugates. Dyes and Pigments, 149, pp.393-398, Dyes and Pigments volume 149 p. 393 2018 1873-3743
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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Collections
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
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