- Title
- Photophysicochemical properties and photodynamic therapy activity of highly water-soluble Zn (II) phthalocyanines
- Creator
- Oluwole, David O, Sari, Fatma Aslihan, Prinsloo, Earl, Dube, Edith, Yuzer, Abdulcelil, Nyokong, Tebello, Ince, Mine
- Subject
- To be catalogued
- Date
- 2018
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/234507
- Identifier
- vital:50203
- Identifier
- xlink:href="https://doi.org/10.1016/j.saa.2018.05.090"
- Description
- The syntheses of two zinc(II) phthalocyanines (ZnPcs) having either imidazole (ZnPc 1) or pyridiloxy (ZnPc 2) moieties as their macrocycle substituents are reported. Quaternization of the ZnPcs with methyl iodide afforded water soluble cationic phthalocyanines. The photophysical, photochemical properties and photodynamic therapy (PDT) activity of the ZnPcs were studied in solution. The fluorescence quantum yield and lifetime of ZnPc 1 were higher as compared to ZnPc 2. ZnPc 2 afforded higher triplet state (ΦT) and singlet oxygen quantum yields (ΦΔ) in comparison to ZnPc 1. The PDT activity of ZnPcs was investigated against human breast adenocarcinoma cells (MCF–7). The two compounds afforded a very minimal in vitro dark cytotoxicity with 85% viable cells at concentration ≤80 μM. On irradiation of the cells having the ZnPcs, ≥50% cell death was recorded for ZnPc 1 which was also evidenced by the cells photo–micrograph.
- Format
- computer, online resource, application/pdf, 1 online resource (8 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Oluwole, D.O., Sarı, F.A., Prinsloo, E., Dube, E., Yuzer, A., Nyokong, T. and Ince, M., 2018. Photophysicochemical properties and photodynamic therapy activity of highly water-soluble Zn (II) phthalocyanines. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 203, pp.236-243, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy volume 203 p. 236 2018 1386-1425
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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Collections
Prinsloo, Earl (Dr)
RU DST/NRF SARChI for Biotechnology Innovation and Engagement
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
SDG 09. Industry, Innovation and Infrastructure
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Photophysicochemical properties and photodynamic therapy activity.pdf | 794 KB | Adobe Acrobat PDF | View Details Download |