- Title
- Synthesis and characterization of quantum dots designed for biomedical use
- Creator
- Kuzyniak, Weronika, Adegoke, Oluwasesan, Sekhosana, Kutloana E, D'Souza, Sarah, Tshangana, Sesethu Charmaine, Hoffmann, Björn, Ermilov, Eugeny A, Nyokong, Tebello, Höpfner, Michael
- Subject
- To be catalogued
- Date
- 2014
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/241516
- Identifier
- vital:50946
- Identifier
- xlink:href="https://doi.org/10.1016/j.ijpharm.2014.03.037"
- Description
- Semiconductor quantum dots (QDs) have become promising nanoparticles for a wide variety of biomedical applications. However, the major drawback of QDs is their potential toxicity. Here, we determined possible cytotoxic effects of a set of QDs by systematic photophysical evaluation in vitro as well as in vivo. QDs were synthesized by the hydrothermal aqueous route with sizes in the range of 2.0–3.5 nm. Cytotoxic effects of QDs were studied in the human pancreatic carcinoid cell line BON. Cadmium telluride QDs with or without zinc sulfide shell and coated with 3-mercaptopropionic acid (MPA) were highly cytotoxic even at nanomolar concentrations. Capping with L-glutathione (GSH) or thioglycolic acid (TGA) reduced the cytotoxicity of cadmium telluride QDs and cadmium selenide QDs. Determination of the toxicity of QDs revealed IC50 values in the micromolar range. In vivo studies showed good tolerability of CdSe QDs with ZnS shell and GSH capping. We could demonstrate that QDs with ZnS shell and GSH capping exhibit low toxicity and good tolerability in cell models and living organisms. These QDs appear to be promising candidates for biomedical applications such as drug delivery for enhanced chemotherapy or targeted delivery of light sensitive substances for photodynamic therapy.
- Format
- computer, online resource, application/pdf, 1 online resource (8 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- International Journal of Pharmaceutics, Kuzyniak, W., Adegoke, O., Sekhosana, K., D’Souza, S., Tshangana, S.C., Hoffmann, B., Ermilov, E.A., Nyokong, T. and Höpfner, M., 2014. Synthesis and characterization of quantum dots designed for biomedical use. International Journal of Pharmaceutics, 466(1-2), pp.382-389, International Journal of Pharmaceutics volume 466 number 1-2 p. 382 2014 1873-3476
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | Synthesis and characterization of quantum dots.pdf | 742 KB | Adobe Acrobat PDF | View Details |