- Title
- Photosensitizing properties of octacarboxy metallophthalocyanines in aqueous medium and their interaction with bovine serum albumin
- Creator
- Idowu, Mopelola A I, Nyokong, Tebello
- Subject
- To be catalogued
- Date
- 2008
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/264552
- Identifier
- vital:53744
- Identifier
- xlink:href="https://doi.org/10.1016/j.jphotochem.2008.09.003"
- Description
- Photosensitizing properties of aluminium, silicon, zinc and germanium octacarboxy phthalocyanines ((OH)AlOCPc, (OH)2SiOCPc, ZnOCPc and (OH)2GeOCPc) were studied in aqueous medium and in the presence of bovine serum albumin (BSA). Triplet quantum yields increased with increasing atomic number of the central metals of the metallophthalocyanine. The efficiency of singlet oxygen generation via energy transfer from the excited triplet state of the octacarboxy metallophthalocyanines (MOCPcs) to ground state oxygen increased markedly in the presence of BSA. The triplet state lifetimes of the MOCPc complexes in the presence of BSA were found to be longer than in the absence of BSA, ranging from 110 to 580 μs. These complexes bind readily to BSA. Stern–Volmer quenching constant KSV as well as the binding constant kb values were calculated. The probable mechanism of quenching of BSA fluorescence by the MOCPc complexes is by static quenching.
- Format
- computer, online resource, application/pdf, 1 online resource (6 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Journal of Photochemistry and Photobiology A: Chemistry, Idowu, M. and Nyokong, T., 2008. Photosensitizing properties of octacarboxy metallophthalocyanines in aqueous medium and their interaction with bovine serum albumin. Journal of Photochemistry and Photobiology A: Chemistry, 200(2-3), pp.396-401, Journal of Photochemistry and Photobiology A: Chemistry volume 200 number 2 - 3 p. 396 2008 1010-6030
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | Photosensitizing properties of octacarboxy metallophthalocyanines in aqueous medium.pdf | 648 KB | Adobe Acrobat PDF | View Details |