- Title
- The interaction of melatonin and its precursors with aluminium, cadmium, copper, iron, lead, and zinc
- Creator
- Limson, Janice L, Nyokong, Tebello, Daya, Santy
- Subject
- To be catalogued
- Date
- 1998
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/293323
- Identifier
- vital:57075
- Identifier
- xlink:href="https://doi.org/10.1111/j.1600-079X.1998.tb00361.x"
- Description
- Melatonin, a pineal secretory product, and its precursors, tryptophan and serotonin, were examined for their metal binding affinities for both essential and toxic metals: aluminium, cadmium, copper, iron, lead, and zinc. An electrochemical technique, adsorptive stripping voltammetry, showed the varying abilities of melatonin and its precursors to bind the metals in situ. The results show that the following metal complexes were formed: aluminium with melatonin, tryptophan, and serotonin; cadmium with melatonin and tryptophan; copper with melatonin and serotonin; iron(III) with melatonin and serotonin; lead with melatonin, tryptophan, and serotonin; and zinc with melatonin and tryptophan. Iron(II) showed the formation of an in situ complex with tryptophan only. These studies suggest a further role for melatonin in the reduction of free radical generation and metal detoxification, and they may explain the accumulation of aluminium in Alzheimer's disease.
- Format
- computer, online resource, application/pdf, 1 online resource (7 pages), pdf
- Publisher
- Wiley Library Online
- Language
- English
- Relation
- Journal of Pineal Research, Limson, J., Nyokong, T. and Daya, S., 1998. The interaction of melatonin and its precursors with aluminium, cadmium, copper, iron, lead, and zinc: an adsorptive voltammetric study. Journal of pineal research, 24(1), pp.15-21, Journal of Pineal Research volume 24 number 1 p. 15 1998 1600-079X
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Wiley Library Online Terms of Use Statement (https://onlinelibrary.wiley.com/terms-and-conditions)
- Rights
- Closed Access
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- Visitors: 459
- Downloads: 82
Collections
Daya, Santylal (Prof)
Limson, Janice (Prof)
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
RU Department of Pharmacy
SDG 03. Good Health and Well-Being
SDG 09. Industry, Innovation and Infrastructure
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|---|---|---|---|---|---|---|---|
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