- Title
- Asymmetrical zinc (II) phthalocyanines conjugated to metal tungstate nanoparticles for photoinactivation of Staphylococcus aureus
- Creator
- Mgidlana, Sithi, Managa, Muthumuni, Nyokong, Tebello
- Subject
- To be catalogued
- Date
- 2022
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/295718
- Identifier
- vital:57372
- Identifier
- xlink:href="https://doi.org/10.1080/00958972.2022.2090837"
- Description
- In this study, we report for the first time on the photodynamic antimicrobial chemotherapy (PACT) of asymmetrical zinc(II) phthalocyanines and their conjugates with nickel tungstate (NiWO4), cobalt tungstate (CoWO4) and bismuth tungstate (Bi2WO6) nanoparticles. CoWO4, NiWO4 and Bi2WO6 were capped with glutathione and covalently linked to three asymmetrical zinc(II) phthalocyanines for PACT. The plate count method was used to investigate the effect of covalently linking asymmetrical zinc(II) phthalocyanines to nanoparticles under light (for PACT against Staphylococcus aureus) and in the dark. Both Pc complexes and the conjugates indicated minimum dark-toxicity. The conjugates showed greater antimicrobial activity against a gram-positive and drug resistant bacteria, Staphylococcus aureus, than Pc complexes alone.
- Format
- computer, online resource, application/pdf, 1 online resource (15 pages), pdf
- Publisher
- Taylor and Francis Online
- Language
- English
- Relation
- Journal of Coordination Chemistry, Mgidlana, S., Managa, M. and Nyokong, T., 2022. Asymmetrical zinc (II) phthalocyanines conjugated to metal tungstate nanoparticles for photoinactivation of Staphylococcus aureus. Journal of Coordination Chemistry, 75(7-8), pp.1097-1111, Journal of Coordination Chemistry volume 75 number 7-8 p. 1097 2022 1029-0389
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Taylor and Francis Online Terms and Conditions Statement (https://www.tandfonline.com/terms-and-conditions)
- Rights
- Open Access
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Collections
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
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