- Title
- Photodynamic activity of novel cationic porphyrins conjugated to graphene quantum dots against Staphylococcus aureus
- Creator
- Magaela, Bridged N, Makola, Lekgowa C, Managa, Muthumuni, Nyokong, Tebello
- Subject
- To be catalogued
- Date
- 2022
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/295797
- Identifier
- vital:57379
- Identifier
- xlink:href="https://doi.org/10.1142/S1088424622500316"
- Description
- Novel 5-(pyridyl)-10-15-20-tris(4-bromophenyl) porphyrin (complex 1), indium metal derivative (complex 2), and quaternized derivative (complex 3) were synthesized and conjugated to graphene quantum dots (GQDs). The conjugation of the porphyrins to GQDs was through ππ-ππ stacking. Herein, the ππ-ππ stacking approach was used to avoid covalent conjugation which might compromise the intrinsic chemical and physical properties. The photodynamic activities of the proposed nanomaterials were assessed towards Staphylococcus aureus cell obliteration. The photophysical properties of the prepared complexes were also studied prior to the application. Moreover, a decrease in fluorescence lifetimes was observed upon metalation of complex 1. As anticipated, singlet oxygen quantum yield (ΦΔ)ΦΔ) increased notably upon heavy metal (indium) insertion and upon composite formation. Antimicrobial photodynamic therapy comparative studies were done on quaternized and unquaternized indium porphyrins conjugated to GQDs. Complex 3-GQDs exhibited the highest antibacterial activities compared to other complexes, and this was attributed to the high ΦΔΦΔ which plays an imperative role in photodynamic therapy applications.
- Format
- computer, online resource, application/pdf, 1 online resource (11 pages), pdf
- Publisher
- World Scientific Publishing
- Language
- English
- Relation
- Journal of Porphyrins and Phthalocyanines, Magaela, N.B., Makola, L.C., Managa, M. and Nyokong, T., 2022. Photodynamic activity of novel cationic porphyrins conjugated to graphene quantum dots against Staphylococcus aureus. Journal of Porphyrins and Phthalocyanines, 26(05), pp.392-402, Journal of Porphyrins and Phthalocyanines volume 26 number 05 p. 392 2022 1099-1409
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the World Scientific Copyright and Permissions Statement (https://0-www.worldscientific.com.wam.seals.ac.za/page/permissions)
- Rights
- Closed Access
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Collections
Nyokong, Tebello (Distinguished Professor)
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
RU Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Photodynamic activity of novel cationic porphyrins conjugated to graphene quantum dots against Staphylococcus aureus.pdf | 824 KB | Adobe Acrobat PDF | View Details Download |