- Title
- Ga III triarylcorroles with push–pull substitutions
- Creator
- Niu, Yingjie, Wang, Lin, Guo, Yingxin, Zhu, Weihua, Soy, Rodah C, Babu, Balaji, Mack, John, Nyokong, Tebello, Xu, Haijun, Liang, Xu
- Subject
- To be catalogued
- Date
- 2022
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/300079
- Identifier
- vital:57890
- Identifier
- xlink:href="https://doi.org/10.1039/D2DT01262F"
- Description
- Two A2B type H3corroles and two GaIIItriarylcorroles with carbazole substitutions at 10-positions were synthesized and characterized. An analysis of structure–property relationships of the corroles has been carried out by investigating the optical spectroscopy of the dyes to trends predicted in DFT and TD-DFT calculations. Interestingly, the photodynamic therapy (PDT) and photodynamic antimicrobial chemotherapy (PACT) activity properties of the GaIIItriarylcorroles were determined against the MCF-7 breast cancer line, and Staphyloccocus aureus (S. aureus) and Escherichia coli (E. coli), respectively. The cationic G-2Q species exhibited the most favorable properties with an IC50 value of 7.8 μM against MCF-7 cells, and Log reduction values of 7.78 and 3.26 against planktonic S. aureus and E. coli at 0.5 and 10 μM, respectively.
- Format
- computer, online resource, application/pdf, 1 online resource (9 pages), pdf
- Publisher
- Royal Society of Chemistry
- Language
- English
- Relation
- Dalton Transactions, Niu, Y., Wang, L., Guo, Y., Zhu, W., Soy, R.C., Babu, B., Mack, J., Nyokong, T., Xu, H. and Liang, X., 2022. Ga III triarylcorroles with push–pull substitutions: synthesis, electronic structure and biomedical applications. Dalton Transactions, 51(27), pp.10543-10551, Dalton Transactions volume 51 number 27 p. 10543 2022 1477-9234
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Royal Society of Chemistry Terms and Conditions Statement (https://0-www.rsc.org.wam.seals.ac.za/help-legal/)
- Rights
- Open Access
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Collections
Mack, John (Associate Prof)
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | Ga III triarylcorroles with push–pull substitutions.pdf | 2 MB | Adobe Acrobat PDF | View Details |