- Title
- Design and fabrication of electrochemical sensor based on molecularly imprinted polymer loaded onto silver nanoparticles for the detection of 17-β-Estradiol
- Creator
- Regasa, Melkamu Biyana, Nyokong, Tebello
- Subject
- To be catalogued
- Date
- 2022
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/300287
- Identifier
- vital:57913
- Identifier
- xlink:href="https://doi.org/10.1002/jmr.2978"
- Description
- In this research report, we prepared an electrochemical sensor based on the molecularly imprinted poly(p-aminophenol) supported by silver nanoparticles capped with 2-mercaptobenzoxazole for the selective and sensitive detection of endocrine disrupting 17-β-estradiol (E2). The electropolymerization of the functional monomer prepared the proposed molecularly imprinted polymer (MIP) composite-based sensor in the presence of E2 as a template. The recognition materials were characterized using Fourier transform infrared, cyclic voltammetry (CV), square wave voltammetry (SWV), scanning electron microscopy, energy-dispersive X-ray spectroscopy and X-ray powder diffraction techniques. The electrochemical measurements were performed by employing both CV and SWV methods. We did the optimization of critical parameters affecting the sensor performances through the experimental design and verification. The developed sensor showed a linear range from 10 pM to 100 nM with the calculated quantification and detection limits of 1.86 and 6.19 pM, respectively. The incorporation of AgNP with high electrical conductivity into the MIP matrix enhanced the sensor's performance. Furthermore, the sensor was applied to determine E2 in real water samples without any sample preconcentration steps to achieve the percent recovery of 91.87% to 98.36% and acceptable reusability and storage stability performances.
- Format
- computer, online resource, application/pdf, 1 online resource (11 pages), pdf
- Publisher
- Wiley Library Online
- Language
- English
- Relation
- Journal of Molecular Recognition, Regasa, M.B. and Nyokong, T., 2022. Design and fabrication of electrochemical sensor based on molecularly imprinted polymer loaded onto silver nanoparticles for the detection of 17‐β‐Estradiol. Journal of Molecular Recognition, p.e2978, Journal of Molecular Recognition p.e. 2978 2022 1099-1352
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Wiley Library Online Terms of Use Statement (https://onlinelibrary.wiley.com/terms-and-conditions)
- Rights
- Closed Access
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Collections
Nyokong, Tebello (Distinguished Professor)
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
RU Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Design and fabrication of electrochemical sensor based on molecularly imprinted polymer.pdf | 712 KB | Adobe Acrobat PDF | View Details Download |