- Title
- Determination of 2′, 3′-Dideoxyinosine Using Iron (II) Phthalocyanine Modified Carbon Paste Electrode
- Creator
- Ozoemena, Kenneth I, Stefan, Raluca-Ioana, Nyokong, Tebello
- Subject
- To be catalogued
- Date
- 2004
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/300298
- Identifier
- vital:57914
- Identifier
- xlink:href="https://doi.org/10.1081/AL-200031940"
- Description
- An amperometric sensor, based on carbon paste impregnated with iron (II) phthalocyanine complex (FePc), has been constructed for the assay of anti‐HIV agent dideoxyinosine (didanosine, DDI). Using chronoamperometry (E = +1.04 V versus Ag/AgCl) technique, the amperometric sensor can be used reliably for dideoxyinosine assay at pH 7.4 phosphate buffer in the 1.5–9.5 nmol/L concentration range with a detection limit of 5.7 × 10−10 mol/L. The surface of the electrode can easily be regenerated by simple polishing, obtaining a fresh surface ready for use in a new assay. The new amperometric sensor proved to be highly reliable for the assay of dideoxyinosine purity in raw material as well as for the uniformity content test of Videx® tablets.
- Format
- computer, online resource, application/pdf, 1 online resource (8 pages), pdf
- Publisher
- Taylor and Francis Online
- Language
- English
- Relation
- Analytical Letters, Ozoemena, K.I., Stefan, R.I. and Nyokong, T., 2004. Determination of 2′, 3′‐Dideoxyinosine Using Iron (II) Phthalocyanine Modified Carbon Paste Electrode. Analytical letters, 37(13), pp.2641-2648, Analytical Letters volume 37 number 13 p. 2641 2004 1532-236X
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Taylor and Francis Online Terms and Conditions Statement (https://www.tandfonline.com/terms-and-conditions)
- Rights
- Open Access
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Collections
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Determination of 2′, 3′‐Dideoxyinosine Using Iron (II) Phthalocyanine Modified Carbon Paste Electrode.pdf | 292 KB | Adobe Acrobat PDF | View Details Download |