- Title
- Melatonin generates singlet oxygen on laser irradiation but acts as a quencher when irradiated by lamp photolysis
- Creator
- Maharaj, Deepa S, Molell, H, Antunes, Edith M, Maharaj, Hiren, Maree, D M, Nyokong, Tebello, Glass, Beverley D, Daya, Santy
- Subject
- To be catalogued
- Date
- 2005
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/300335
- Identifier
- vital:57917
- Identifier
- xlink:href="https://doi.org/10.1111/j.1600-079X.2004.00185.x"
- Description
- Melatonin, a naturally occurring chemical mediator, although assigned a diverse range of functions, has attracted interest in recent years because of its ability to function as a free radical scavenger. Because of the implications of singlet oxygen in neurotoxicity, the objective of the study was to investigate the ability of melatonin to quench singlet oxygen generated using laser irradiation or lamp photolysis. The results show that melatonin produces radicals upon laser irradation while the lamp photolysis studies show that melatonin is able to scavenge singlet oxygen produced by naphthalene. While melatonin is a free radical scavenger under biological conditions, it acts as a generator of singlet oxygen and or radicals (as ΦΔ is 1.41) when irradiated with laser light, implying that it has the potential to be used in photodynamic therapy in the destruction of tumors.
- Format
- computer, online resource, application/pdf, 1 online resource (4 pages), pdf
- Publisher
- Wiley Library Online
- Language
- English
- Relation
- Journal of Pineal Research, Maharaj, D.S., Molell, H., Antunes, E.M., Maharaj, H., Maree, D.M., Nyokong, T., Glass, B.D. and Daya, S., 2005. Melatonin generates singlet oxygen on laser irradiation but acts as a quencher when irradiated by lamp photolysis. Journal of pineal research, 38(3), pp.153-156, Journal of Pineal Research volume 38 number 3 p. 153 2005 1600-079X
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Wiley Library Online Terms of Use Statement (https://onlinelibrary.wiley.com/terms-and-conditions)
- Rights
- Closed Access
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Collections
Daya, Santylal (Prof)
Antunes, Edith Martins (Dr)
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
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| View Details | SOURCE1 | Melatonin generates singlet oxygen on laser irradiation but acts as a quencher.pdf | 619 KB | Adobe Acrobat PDF | View Details |