- Title
- Pharmacokinetics of phenylpropanolamine in humans after a single dose study
- Creator
- Dowse, Roslind, Haigh, John M, Kanfer, Isadore
- Date
- 1987
- Type
- Article
- Identifier
- vital:6363
- Identifier
- http://hdl.handle.net/10962/d1006059
- Description
- The pharmacokinetics of phenylpropanolamine have been studied in healthy human volunteers following the oral administration of an aqueous solution of the drug (50 mg/200 ml). Blood and urine samples collected throughout the trial were assayed using HPLC with UV detection. The drug was shown to be rapidly absorbed with a mean tmax of 1.47 ± 0.49 h and a mean elimination half-life of 4.0 ± 0.5 h. Phenylpropanolamine is predominantly excreted via the kidney with a mean renal clearance of 0.646 ± 0.089 liter/kg/h and 90.2 ± 1.7% excreted unchanged in the urine. The data were not well described using conventional one or two body compartment models. However, the incorporation of a discontinuous absorption phase into the models resulted in an improved overall fit with better characterisation of the absorption phase.
- Format
- 8 pages, pdf
- Language
- English
- Relation
- Dowse, R. and Haigh, J.M. and Kanfer, I. (1987) Pharmacokinetics of phenylpropanolamine in humans after a single dose study. International Journal of Pharmaceutics, 39 (1/2). pp. 141-148. Available: http://dx.doi.org/10.1016/0378-5173(87)90209-2
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Kanfer, Isadore (Prof)
Haigh, John M (Prof)
Dowse, Ros (Emeritus Assoc Prof)
RU Department of Pharmacy
SDG 03. Good Health and Well-Being
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