In vitro permeation of progesterone from a gel through the shed skin of three different snake species

Title: In vitro permeation of progesterone from a gel through the shed skin of three different snake species
Creator: Haigh, John M, Beyssac, E, Chanet, L, Aiache, J M
Date: 1998
Type: Article
Identifier: vital:6366
Identifier: http://hdl.handle.net/10962/d1006066
Description: The in vitro diffusion of progesterone from a gel formulation using the European Pharmacopoeia method for transdermal dosage forms is described. The membranes used were the dorsal and ventral portions of the shed skin of three different species of snake. Considerable differences are apparent between the dorsal and ventral sites and between the different species of snake. The dorsal area shows better permeability for progesterone and the permeability order for the different species is python>cobra>viper. These differences may be due to the thickness of the skin and the hinge:scale ratio. The results indicate that shed snake skin is not a model membrane for human skin.
Format: 10 pages, pdf
Language: English
Relation: Haigh, J.M. and Beyssac, E. and Chanet, L. and Aiache, J.M. (1998) In vitro permeation of progesterone from a gel through the shed skin of three different snake species. International Journal of Pharmaceutics, 170 (2). pp. 151-156. Available: http://dx.doi.org/10.1016/S0378-5173(98)00064-7

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