- Title
- A stability-indicating liquid chromatographic method for the analysis of erythromycin in stored biological fluids using amperometric detection
- Creator
- Stubbs, Christopher, Haigh, John M, Kanfer, Isadore
- Date
- 1987
- Type
- Article
- Identifier
- vital:6430
- Identifier
- http://hdl.handle.net/10962/d1006592
- Description
- A simple, sensitive and reliable high-performance liquid chromatographic procedure has been developed for the determination of erythromycin in human serum and urine using amperometric detection. A solid-phase extraction procedure was used followed by chromatography on a reverse-phase column. The mean recovery of erythromycin from serum and urine was 80%. This method allows both erythromycin and its principle degradation product, anhydroeythromycin, to be determined during a period of sample storage at 4 degree C and minus 15 degree C. The method is sufficiently sensitive and precise and is thus highly suited for use in both pharmacokinetic and stability studies.
- Format
- 11 pages, pdf
- Language
- English
- Relation
- Stubbs, C. and Haigh, J.M. and Kanfer, I. (1987) A stability-indicating liquid chromatographic method for the analysis of erythromycin in stored biological fluids using amperometric detection. Journal of Liquid Chromatography, 10 (11). pp. 2547-2557. Available: http://dx.doi.org/10.1080/01483918708068934
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Kanfer, Isadore (Prof)
Haigh, John M (Prof)
RU Department of Pharmacy
SDG 03. Good Health and Well-Being
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