In vitro systems for the assessment of drug release from topical formulations and trans-membrane permeation

Smith, Eric W; Haigh, John M

Title: In vitro systems for the assessment of drug release from topical formulations and trans-membrane permeation
Creator: Smith, Eric W, Haigh, John M
Date: 1989
Type: Book chapter
Identifier: vital:6441
Identifier: http://hdl.handle.net/10962/d1006628
Description: Numerous experimental methods have been developed to investigate drug release from vehicles and the percutaneous absorption of topically applied chemicals. The objective of this research is often to find correlation between laboratory results and the transdermal absorption experienced by living subjects so that in vivo experimentation may be curtailed. In many instances, the diverse experimental techniques tend to obscure absorption-controlling factors and complicate inter study comparisons, rather than clarify the complex transdermal absorption process. Moreover, lack of agreement between results may occasionally be ascribed to shortcomings in the in vitro methodology employed. The benefits of using an in vitro cell system for the preliminary testing of drug permeation in the laboratory are obvious. The environmental and diffusion variables may be controlled in an attempt to elucidate specific factors affecting the kinetic processes and drug bioavailability. Investigations are complex because of the multiple, interrelated events underlying the processes of drug partitioning from the applied vehicle and diffusion through the portals of the stratum corneum to the myriad of metabolic, binding, and clearance activities in the lower epidermal and dermal strata.
Format: 43 pages, pdf
Language: English
Relation: Smith, E.W. and Haigh, J.M. (1989) In vitro systems for the assessment of drug release from topical formulations and trans-membrane permeation. In: Percutaneous absorption : mechanisms - methodology - drug delivery. Marcel Dekker, New York, pp. 465-508.

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