- Title
- Assessing penetration enhances for topical corticosteroids
- Creator
- Smith, Eric W, Haigh, John M
- Date
- 1995
- Type
- Book chapter
- Identifier
- vital:6442
- Identifier
- http://hdl.handle.net/10962/d1006629
- Description
- From introduction: Topical corticosteroids have been used for a wide range of dermatological conditions for the last 4 decades. For many years the topical delivery system was a relatively simple cream or ointment base, with little thought given to improving the formulation as far as drug delivery was concerned. The main emphasis in the initial stages of development was on the alteration of the corticosteroid molecule, in an attempt to produce moieties with a higher intrinsic topical effect with lower mineralocorticoid side effects. Once this avenue of research was exhausted, attention was placed on the lipophilicity of the molecule with the production of various types of esters in an attempt to produce molecules which would pass through the stratum corneum (SC) with reasonable ease. In recent years the nature of the semisolid drug delivery base has received considerable attention.2-5The nature of the vehicle has a profound effect on the rate of release of the topical corticosteroid from the formulation and its passage through the SC. One of the most important aspects of the formulation of the base is the inclusion of substances which aid this trads-SC diffusion, the so-called penetration enhancers.6The modes of action of the various different types of penetration enhancers are reviewed elsewhere in this book. The best method for the assessment of the release of corticosteroids from topical formulations is obviously the clinical tri~. Clinical trials, however, are laborious, costly, and difficult to mount. Patients suffering from dermatological complaints are not ideal subjects for the testing of topical corticosteroid formulations as it is difficult to obtain standardized lesions which are necessary for the comparison of results between formulations. Alternatively, a number of in vitro models exist for this type of assessment, but it is often problematic to obtain correlation with the in vivo situation.
- Format
- 5 pages, pdf
- Language
- English
- Relation
- Smith, E.W. and Haigh, J.M. (1995) Assessing penetration enhances for topical corticosteroids. In: Percutaneous Penetration Enhancers. CRC Press, Boca Raton, USA, pp. 453-457.
- Hits: 683
- Visitors: 876
- Downloads: 216
Collections
Haigh, John M (Prof)
RU Department of Pharmacy
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCEPDF | 2 MB | Adobe Acrobat PDF | View Details |