- Title
- Photodynamic inactivation of methicillin-resistant Staphylococcus aureus using pyrrolidinium containing Schiff base phthalocyanines
- Creator
- Sindelo, Azole, Sen, Pinar, Nyokong, Tebello
- Subject
- To be catalogued
- Date
- 2023
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/360449
- Identifier
- vital:65089
- Identifier
- xlink:href="https://doi.org/10.1016/j.jphotochem.2022.114535"
- Description
- New tetra-substituted zinc and indium Schiff base phthalocyanines (ZnPc and InPc, respectively) are synthesized and characterized herein. The ethyl pyrrolidine (ZnPc-2, InPc-2) and propyl pyrrolidine (ZnPc-3, InPc-3) substituted Schiff base Pcs were reacted with methyl iodide to form their cationic derivatives (ZnPc-2Q, InPc-2Q, ZnPc-3Q, and InPc-3Q, respectively). The photophysical and photochemical properties of the Pcs were studied. The cationic Pcs generated higher singlet oxygen quantum yield in aqueous media than the neutral Pcs. The photoinactivation of Methicillin-resistant Staphylococcus aureus (MRSA) and Methicillin-sensitive Staphylococcus aureus (MSSA) strains was evaluated. 5 µM ZnPc-3Q and InPc-3Q inactivated 100 % of the MSSA and MRSA while 5 µM ZnPc-2Q and InPc-2Q eradicated 100 % for MSSA and 97.2 % and 98.7 % (respectively) of the MRSA. The photodynamic antimicrobial chemotherapy studies depended on singlet oxygen ability, the charges, and the extension of the alkyl groups.
- Format
- computer, online resource, application/pdf, 1 online resource (9 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Journal of Photochemistry and Photobiology A: Chemistry, Sindelo, A., Sen, P. and Nyokong, T., 2023. Photodynamic inactivation of methicillin-resistant Staphylococcus aureus using pyrrolidinium containing Schiff base phthalocyanines. Journal of Photochemistry and Photobiology A: Chemistry, 438, p.114535, Journal of Photochemistry and Photobiology A: Chemistry volume 438 p. 114535 2023 1873-2666
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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Collections
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Photodynamic inactivation of methicillin-resistant Staphylococcus aureus.pdf | 823 KB | Adobe Acrobat PDF | View Details Download |