- Title
- Characterisation of plasmodial transketolases and identification of potential inhibitors: an in silico study
- Creator
- Boateng, Rita A, Tastan Bishop, Özlem, Musyoka, Thommas M
- Subject
- To be catalogued
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/429372
- Identifier
- vital:72605
- Identifier
- xlink:href="https://doi.org/10.1186/s12936-020-03512-1"
- Description
- Plasmodial transketolase (PTKT) enzyme is one of the novel pharmacological targets being explored as potential anti-malarial drug target due to its functional role and low sequence identity to the human enzyme. Despite this, features contributing to such have not been exploited for anti-malarial drug design. Additionally, there are no anti-malarial drugs targeting PTKTs whereas the broad activity of these inhibitors against PTKTs from other Plasmodium spp. is yet to be reported. This study characterises different PTKTs [Plasmodium falciparum (PfTKT), Plasmodium vivax (PvTKT), Plasmodium ovale (PoTKT), Plasmodium malariae (PmTKT) and Plasmodium knowlesi (PkTKT) and the human homolog (HsTKT)] to identify key sequence and structural based differences as well as the identification of selective potential inhibitors against PTKTs.
- Format
- computer, online resource, application/pdf, 1 online resource (19 pages), pdf
- Publisher
- Springer Nature
- Language
- English
- Relation
- Malaria Journal, Boateng, R.A., Tastan-Bishop, Ö. and Musyoka, T.M. (2020) Characterisation of plasmodial transketolases and identification of potential inhibitors: an in silico study. Malaria Journal. 19: 442, Malaria Journal volume 19 p. 442 2020 1475-2875
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the SpringerNature Statement (https://www.biomedcentral.com/)
- Rights
- Open Access
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Tastan Bishop, Ozlem (Prof)
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Characterisation of plasmodial transketolases and identification of potential inhibitors.pdf | 8 MB | Adobe Acrobat PDF | View Details Download |