- Title
- Chemical constituents, antioxidant and cytotoxicity properties of Leonotis leonurus used in the folklore management of neurological disorders in the Eastern Cape, South Africa
- Creator
- Tonisi, Sipho, Okaiyeto, Kunle, Hoppe, Heinrich C, Mabinya, Leonard V, Nwodo, Uchechukwu U, Okoh, Anthony I
- Subject
- To be catalogued
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/429384
- Identifier
- vital:72606
- Identifier
- xlink:href="https://doi.org/10.1007/s13205-020-2126-5"
- Description
- In the present study, we evaluated the phytochemical compounds and antioxidant properties of chloroform, ethanol and acetone extracts for leaves and flowers of Leonutus leonurus (L. leonurus) alongside with their cytotoxic effects on human cervical carcinoma (HeLa) cell lines. The phytochemical compounds present in the leaves and flowers of L. leonurus included; phenolics, flavonoids and alkaloids. Their radicals scavenging effects against 2, 2-diphenyl-1-picrylhydrazyl [DPPH] 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulphonate) [ABTS·+], hydrogen peroxide, nitric oxide as well as metal chelating activities showed dose-dependent activities. Gas chromatography-mass spectrometry (GCMS) analyses revealed the presence of important bioactive compounds, which are associated with antioxidant; and the extracts exhibited toxicity effect against HeLa cells. The findings from this study divulge extracts of L. leonurus as prospective sources of antioxidant and anticancer agents; and hence, further study on their neuroprotective potentials becomes imperative.
- Format
- computer, online resource, application/pdf, 1 online resource (14 pages), pdf
- Publisher
- Springer
- Language
- English
- Relation
- 3 Biotech, Tonisi, S., Okaiyeto, K., Hoppe, H.C., Mabinya, L.V., Nwodo, U.U. and Okoh, A.I. (2020) Chemical constituents, antioxidant and cytotoxicity properties of Leonotis leonurus used in the folklore management of neurological disorders in the Eastern Cape, South Africa. 3 Biotech. 10: 141, 3 Biotech volume 10 p. 141 2020 2190-5738
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the SpringerLink Terms of Use Statement ( https://link.springer.com/termsandconditions)
- Rights
- Open Access
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Collections
Hoppe, Heinrich C (Prof)
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | Chemical constituents, antioxidant and cytotoxicity properties of Leonotis leonurus used in the folklore.pdf | 1 MB | Adobe Acrobat PDF | View Details |