- Title
- Plant-Based Synthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Salvia officinalis: Characterization and its Antiplasmodial Activity
- Creator
- Okaiyeto, Kunle, Hoppe, Heinrich C, Okoh, Anthony I
- Subject
- To be catalogued
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/429472
- Identifier
- vital:72613
- Identifier
- xlink:href="https://doi.org/10.1007/s10876-020-01766-y"
- Description
- In the present study, an aqueous leaf extract of Salvia officinalis was used to synthesize silver nanoparticles (AgNPs) and characterized with different techniques such as UV–vis spectroscopy, Fourier transform infrared (FTIR), X-ray diffraction (XRD), Scanning electron microscope (SEM), Energy dispersive X-ray spectroscopy (EDX), Transmission electron microscope (TEM) and thermogravimetric analysis (TGA). Subsequently, its cytotoxic effect against human cervix adenocarcinoma (HeLa) cells and antiplasmodial activity against Plasmodium falciparum were investigated. UV–vis spectrum of AgNPs displayed an absorption peak at 323 nm and TEM result revealed it to be spherical in shape with average size of 41 nm. FTIR results highlighted the key bioactive compounds that could be responsible for the reduction and capping of AgNPs and XRD analysis showed its crystalline nature with a face-centered cubic (fcc) structure. The synthesized AgNPs was found to be less cytotoxic against HeLa cells line and demonstrated good antiplasmodial potential (IC50 = 3.6 µg/mL). Findings from this study indicated that the AgNPs could serve as a template in the development of new drugs for the control of malaria and hence, further study is needed to identify and characterize the potent molecules that suppress the malaria parasite.
- Format
- computer, online resource, application/pdf, 1 online resource (9 pages), pdf
- Publisher
- SpringerLink
- Language
- English
- Relation
- Journal of Cluster Science, Okaiyeto, K., Hoppe, H.C. and Okoh, A.I. (2020) Plant-Based Synthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Salvia officinalis: Characterization and its Antiplasmodial Activity. Journal of Cluster Science. 32. p.101-109, Journal of Cluster Science volume 32 p. 101 2020 1572-8862
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the SpringerLink Terms of Use Statement ( https://link.springer.com/termsandconditions)
- Rights
- Open Access
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Collections
Hoppe, Heinrich C (Prof)
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Plant-Based Synthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Salvia officinalis.pdf | 1 MB | Adobe Acrobat PDF | View Details Download |