- Title
- Guardian of the furnace: mitochondria, TRAP1, ROS and stem cell maintenance
- Creator
- Kadye, Rose, Kramer, Adam H, Joos-Vandewalle, Julia, Parsons, Michelle, Njengele, Zikhona, Hoppe, Heinrich C, Prinsloo, Earl
- Subject
- To be catalogued
- Date
- 2014
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/431119
- Identifier
- vital:72745
- Identifier
- xlink:href="https://doi.org/10.1002/iub.1234"
- Description
- Mitochondria are key to eukaryotic cell survival and their activity is linked to generation of reactive oxygen species (ROS) which in turn acts as both an intracellular signal and an effective executioner of cells with regards to cellular senescence. The mitochondrial molecular chaperone tumor necrosis factor receptor associated protein 1 (TRAP1) is often termed the cytoprotective chaperone for its role in cancer cell survival and protection from apoptosis. Here, we hypothesize that TRAP1 serves to modulate mitochondrial activity in stem cell maintenance, survival and differentiation.
- Format
- computer, online resource, application/pdf, 1 online resource (3 pages), pdf
- Publisher
- Wiley
- Language
- English
- Relation
- IUBMB Life, Kadye, R., Kramer, A.H., Joos‐Vandewalle, J., Parsons, M., Njengele, Z., Hoppe, H. and Prinsloo, E., 2014. Guardian of the furnace: mitochondria, TRAP1, ROS and stem cell maintenance. IUBMB life, 66(1), pp.42-45, IUBMB Life volume 66 number 1 p. 62 2014 1521-6551
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Wiley Library Online Terms of Use Statement (https://onlinelibrary.wiley.com/terms-and-conditions)
- Rights
- Closed Access
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Collections
Prinsloo, Earl (Dr)
RU DST/NRF SARChI for Biotechnology Innovation and Engagement
Hoppe, Heinrich C (Prof)
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | Guardian of the Furnace.pdf | 658 KB | Adobe Acrobat PDF | View Details |