- Title
- Mitochondrial STAT3 and reactive oxygen species: a fulcrum of adipogenesis?
- Creator
- Kramer, Adam H, Kadye, Rose, Houseman, Pascalene S, Prinsloo, Earl
- Subject
- To be catalogued
- Date
- 2015
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/431674
- Identifier
- vital:72795
- Identifier
- xlink:href="https://doi.org/10.1080/21623996.2015.1084084"
- Description
- The balance between cellular lineages can be controlled by reactive oxygen species (ROS). Cellular differentiation into adipocytes is highly dependent on the production of ROS to initiate the process through activation of multiple interlinked factors that stimulate mitotic clonal expansion and cellular maturation. The signal transducer and activator of transcription family of signaling proteins have accepted roles in adipogenesis and associated lipogenesis. Non-canonical mitochondrial localization of STAT3 and other members of the STAT family however opens up new avenues for investigation of its role in the aforementioned processes. Following recent observations of differences in mitochondrially localized serine 727 phosphorylated STAT3 (mtSTAT3-pS727) in preadipocytes and adipocytes, here, we hypothesize and speculate further on the role of mitochondrial STAT3 in adipogenesis.
- Format
- computer, online resource, application/pdf, 1 online resource (10 pages), pdf
- Publisher
- Taylor and Francis
- Language
- English
- Relation
- JAK-STAT, Kramer, A.H., Kadye, R., Houseman, P.S. and Prinsloo, E., 2015. Mitochondrial STAT3 and reactive oxygen species: a fulcrum of adipogenesis?. JAK-STAT, 4(2), pp.1-10, JAK-STAT volume 4 number 2 p. 1 2015 2162-3996
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Taylor and Francis Online Terms and Conditions Statement (https://www.tandfonline.com/terms-and-conditions)
- Rights
- Closed Access
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Collections
Prinsloo, Earl (Dr)
RU DST/NRF SARChI for Biotechnology Innovation and Engagement
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Mitochondrial STAT3 and reactive oxygen species.pdf | 596 KB | Adobe Acrobat PDF | View Details Download |