- Title
- The effect of ascorbic acid on the photophysical properties and photodynamic therapy activities of zinc phthalocyanine-single walled carbon nanotube conjugate on MCF-7 cancer cells
- Creator
- Ogbodu, Racheal O, Nyokong, Tebello
- Type
- Article
- Identifier
- vital:7286
- Identifier
- http://hdl.handle.net/10962/d1020334
- Description
- Zinc mono carboxy phenoxy phthalocyanine (1) was chemical modified with ascorbic acid via an ester bond to give ZnMCPPc-AA (2). Complexes 2 and 1 were coordinated to single walled carbon nanotubes via π–π interaction to give ZnMCPPc-AA-SWCNT (3) and ZnMCPPc-SWCNT (4) respectively. Complexes 2, 3 and 4 showed better photophysical properties: with improved triplet lifetimes and quantum yields, and singlet oxygen quantum yields when compared to 1 alone. The photodynamic therapy activities of complexes 1, 2, 3 and 4 were tested in vitro on MCF-7 breast cancer cells. Ascorbic acid suppresses the photodynamic therapy effect of 1, due to its ability to reduce oxidative DNA damage as a result of its potent reducing properties. The highest phototoxicity was observed for 4 which resulted in 77% decrease in cell viability, followed by 3 which resulted in 67% decrease in cell viability. This shows the importance of combination therapy, where the phthalocyanines are the photodynamic therapy agents and single walled carbon nanotubes are the photothermal therapy agents.
- Description
- Original publication is available at http://dx.doi.org/10.1016/j.saa.2015.06.063
- Format
- 10 p, pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Ogbodu, R. O. & Nyokong, T. 2015. The effect of ascorbic acid on the photophysical properties and photodynamic therapy activities of zinc phthalocyanine-single walled carbon nanotube conjugate on MCF-7 cancer cells. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 151:174–183. Available: http://dx.doi.org/10.1016/j.saa.2015.06.063.
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Nyokong, Tebello (Distinguished Professor)