- Title
- Photoinactivation of Candida albicans and Escherichia coli using aluminium phthalocyanine on gold nanoparticles
- Creator
- Mthethwa, Thandekile, Nyokong, Tebello
- Type
- Article
- Identifier
- vital:7298
- Identifier
- http://hdl.handle.net/10962/d1020364
- Description
- The conjugates of aluminium phthalocyanine (complex 1) with gold nanorods (complex 1–AuNRs) and bipyramids (complex 1–AuBPs) showed improved singlet oxygen quantum yields of 0.23 and 0.24, respectively, compared to that of complex 1 alone at 0.12. Complex 1 and its conjugates were used for the photoinactivation of fungi (C. albicans) and bacteria cells (E. coli). The Q band absorbances were the same for the Pc alone and when conjugated to AuNPs. The efficiency of these conjugates was evaluated by measuring the log reduction of the microorganisms (C. albicans and E. coli) after irradiation with visible light in the presence of photosensitizers. Aluminium phthalocyanine alone showed log 1.78 and log 2.51 reductions for C. albicans and E. coli respectively. However, the conjugates showed higher photosensitization with log 2.08 and log 3.34 for C. albicans and E. coli, respectively using 1–AuBPs. For complex 1–AuNRs log 2.53 and log 3.71 were achieved for C. albicans and E. coli respectively. The statistical analysis of the results showed that the enhanced photoinactivation observed in both microorganisms was irrespective of the shape of the nanoparticles conjugated. Photoinactivation of C. albicans was less than that of E. coli even though a higher concentration of complex 1 or its conjugates was used in C. albicans.
- Description
- Original publication is available at http://dx.doi.org/10.1039/C4PP00315B
- Description
- Arbortext Advanced Print Publisher 9.1.520/W Unicode
- Description
- Acrobat Distiller 10.0.0 (Windows); modified using iTextSharp 5.5.1 �2000-2014 iText Group NV (AGPL-version); modified using iText� 5.3.3 �2000-2012 1T3XT BVBA (AGPL-version)
- Format
- 11 p., pdf
- Publisher
- Royal Society of Chemistry
- Language
- English
- Relation
- Mthethwa, T. & Nyokong, T. 2015. Photoinactivation of Candida albicans and Escherichia coli using aluminium phthalocyanine on gold nanoparticles. Photochemical and Photobiological Sciences, 14(7):1346-1356. Available: http://dx.doi.org/10.1039/C4PP00315B.
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Nyokong, Tebello (Distinguished Professor)
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