- Title
- Synthesis of N-Substituted phosphoramidic acid esters as “reverse” fosmidomycin analogues
- Creator
- Adeyemi, Christiana M, Hoppe, Heinrich C, Isaacs, Michelle, Klein, Rosalyn, Lobb, Kevin A, Kaye, Perry T
- Subject
- To be catalogued
- Date
- 2019
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/443238
- Identifier
- vital:74101
- Identifier
- https://doi.org/10.1016/j.tet.2019.02.003
- Description
- An efficient synthetic pathway to a series of novel “reverse” fosmidomycin analogues has been developed, commencing from substituted benzylamines. In these analogues, the fosmidomycin hydroxamate moiety is reversed and the tetrahedral methylene carbon adjacent to the phosphonate moiety is replaced by a nitrogen atom bearing different benzyl groups. The resulting phosphonate esters were designed as potential antimalarial “pro-drugs”.
- Format
- 8 pages, pdf
- Language
- English
- Relation
- Tetrahedron, Adeyemi, C.M., Hoppe, H.C., Isaacs, M., Klein, R., Lobb, K.A. and Kaye, P.T., 2019. Synthesis of N-Substituted phosphoramidic acid esters as “reverse” fosmidomycin analogues. Tetrahedron, 75(16), pp.2371-2378. https://doi.org/10.1016/j.tet.2019.02.003, Tetrahedron volume 75 number 16 2371 2378 2019 0040-4020
- Rights
- Author
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
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