- Title
- Synthesis of N-Substituted phosphoramidic acid esters as “reverse” fosmidomycin analogues
- Creator
- Adeyemi, Christiana M, Hoppe, Heinrich C, Isaacs, Michelle, Klein, Rosalyn, Lobb, Kevin A, Kaye, Perry T
- Subject
- To be catalogued
- Date
- 2019
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/447196
- Identifier
- vital:74591
- Identifier
- xlink:href="https://doi.org/10.1016/j.tet.2019.02.003"
- Description
- An efficient synthetic pathway to a series of novel “reverse” fosmidomycin analogues has been developed, commencing from substituted benzylamines. In these analogues, the fosmidomycin hydroxamate moiety is reversed and the tetrahedral methylene carbon adjacent to the phosphonate moiety is replaced by a nitrogen atom bearing different benzyl groups. The resulting phosphonate esters were designed as potential antimalarial “pro-drugs”.
- Format
- computer, online resource, application/pdf, 1 online resource (8 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Tetrahedron, Adeyemi, C.M., Hoppe, H.C., Isaacs, M., Klein, R., Lobb, K.A. and Kaye, P.T., 2019. Synthesis of N-Substituted phosphoramidic acid esters as “reverse” fosmidomycin analogues. Tetrahedron, 75(16), pp.2371-2378, Tetrahedron volume 75 number 16 p. 2371 2019 1464-5416
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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- Visitors: 134
- Downloads: 4
Collections
Klein, Rosalyn (Assoc Prof)
RU Centre for Chemico- and Biomedicinal Research (CCBR)
Lobb, Kevin Allan (Assoc Prof)
Hoppe, Heinrich C (Prof)
Isaacs, Michelle (Mrs)
Kaye, Perry T (Distinguished Fellow Emeritus Professor)
RU Department of Chemistry
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | Synthesis of N-Substituted phosphoramidic acid esters as “reverse” fosmidomycin analogues.pdf | 751 KB | Adobe Acrobat PDF | View Details |