- Title
- Synthesis, characterization and DPPH scavenging activity of some benzimidazole derivatives
- Creator
- Odame, Felix, Krause, Jason, Hosten, Eric C, Betz, Richard, Lobb, Kevin A, Tshentu, Zenixole R, Frost, Carminita L
- Subject
- To be catalogued
- Date
- 2018
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/447209
- Identifier
- vital:74592
- Identifier
- xlink:href="https://dx.doi.org/10.4314/bcse.v32i2.8 "
- Description
- A base-catalyzed conversion of aldehydes to benzimidazoles has been achieved. The compounds have been characterized by IR, NMR, micoranalysis, and GC-MS. The reaction for the formation of benzimidazoles has been monitored with 1 H NMR and IR. The crystal structures of two derivatives, 2-(2- chlorophenyl)-1H-benzimidazole and 2-(1H-benzimidazol-2-yl)-4-nitrophenol, are presented. A study of the DPPH scavenging activity of these compounds showed that 2-(1H-benzimidazol-2-yl)phenol (2), 2-p-tolyl-1Hbenzimidazole (3) and 2-(4-methoxyphenyl)-1H-benzimidazole (7) gave IC50 values 1974, 773 and 800 µM.
- Format
- computer, online resource, application/pdf, 1 online resource (14 pages), pdf
- Publisher
- Bulletin of the Chemical Society of Ethiopia
- Language
- English
- Relation
- Bulletin of the Chemical Society of Ethiopia, Odame, F., Krause, J., Hosten, E.C., Betz, R., Lobb, K., Tshentu, Z.R. and Frost, C.L., 2018. Synthesis, characterization and DPPH scavenging activity of some benzimidazole derivatives. Bulletin of the Chemical Society of Ethiopia, 32(2), pp.271-284, Bulletin of the Chemical Society of Ethiopia volume 32 number 2 p. 271 2018 1726-801X
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Bulletin of the Chemical Society of Ethiopia Open Access Terms and Conditions Statement (https://www.ajol.info/index.php/bcse/about)
- Rights
- Closed Access
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Collections
Lobb, Kevin Allan (Assoc Prof)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
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|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Synthesis, characterization and DPPH scavenging activity of some benzimidazole derivatives.pdf | 714 KB | Adobe Acrobat PDF | View Details Download |