- Title
- Towards the synthesis of coumarin derivatives as potential dual-action HIV-1 protease and reverse transcriptase inhibitors
- Creator
- Olomola, Temitope O, Klein, Rosalyn, Lobb, Kevin A, Sayed, Yasien, Kaye, Perry T
- Subject
- To be catalogued
- Date
- 2010
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/448963
- Identifier
- vital:74774
- Identifier
- xlink:href="https://doi.org/10.1016/j.tetlet.2010.09.121"
- Description
- 3-(Chloromethyl)coumarins, obtained via acid-catalysed cyclisation of salicylaldehyde-derived Baylis– Hillman adducts, have been treated with propargylamine; reaction of the resulting 3-alkynylmethylcoumarins with azidothymidine (AZT) in the presence of a Cu(I) catalyst has afforded a series of cycloaddition products for evaluation, in their own right, as potential dual-action HIV-1 protease and non-nucleoside reverse transcriptase inhibitors, and as scaffolds for further structural elaboration.
- Format
- computer, online resource, application/pdf, 1 online resource (6 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Tetrahedron Letters, Olomola, T.O., Klein, R., Lobb, K.A., Sayed, Y. and Kaye, P.T., 2010. Towards the synthesis of coumarin derivatives as potential dual-action HIV-1 protease and reverse transcriptase inhibitors. Tetrahedron Letters, 51(48), pp.6325-6328, Tetrahedron Letters volume 51 number 48 p. 6325 2010 0040-4039
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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- Visitors: 93
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Collections
Klein, Rosalyn (Assoc Prof)
RU Centre for Chemico- and Biomedicinal Research (CCBR)
Lobb, Kevin Allan (Assoc Prof)
Kaye, Perry T (Distinguished Fellow Emeritus Professor)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | Towards the synthesis of coumarin derivatives as potential dual-action HIV-1 protease and reverse transcriptase inhibitors.pdf | 715 KB | Adobe Acrobat PDF | View Details |