- Title
- Arylquinolinecarboxamides: Synthesis, in vitro and in silico studies against Mycobacterium tuberculosis
- Creator
- Bokosi, Fostino R B, Beteck, Richard M, Jordaan, Audrey, Seldon, Ronnett, Warner, Digby F, Tshiwawa, Tendamudzimu, Lobb, Kevin A, Khanye, Setshaba D
- Subject
- To be catalogued
- Date
- 2021
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/451064
- Identifier
- vital:75015
- Identifier
- xlink:href="https://doi.org/10.1002/jhet.4340"
- Description
- A series of fourteen 6-substituted-2-(methoxyquinolin-3-yl) methyl)-N-(pyridin-3-ylmethyl) benzamides was prepared from commercially available anilines infive simple and convenient synthetic steps. The structures of all new productswere confirmed by routine spectroscopic methods: IR,1Hand13 CNMR,andHRMS (electrospray ionization). The resulting arylquinolinecarboxamides weresubjected to biological screening assay forin vitroinhibitory activity againstMyco-bacterium tuberculosis (Mtb) H37Rv strain. Several compounds exhibited modestantitubercular activity with compounds8–11,15and19exhibiting MIC90valuesin the range of 32–85μM. The antitubercular data suggested that inhibition ofMtbcan be imparted by the introduction of a non-polar substituent on C-6 of thequinoline scaffold. Further, to understandthepossiblemodeofactionoftheseries, the reported compounds and bedaquiline were subjected toin silicodock-ing studies againstMtbATPase to determine their potential to interfere with themycobacterial adenosine triphosphate (ATP) synthase. The results showed thatthese compounds have the potential toserve as antimycobacterial agents.In silicoADME pharmacokinetic prediction results showed the ability of thesearylquinolinecarcboxamides to be absorbed, distributed, metabolized andexcreted efficiently.
- Format
- computer, online resource, application/pdf, 1 online resource (12 pages), pdf
- Publisher
- Wiley
- Language
- English
- Relation
- Journal of Heterocyclic Chemistry, Bokosi, F.R., Beteck, R.M., Jordaan, A., Seldon, R., Warner, D.F., Tshiwawa, T., Lobb, K. and Khanye, S.D., 2021. Arylquinolinecarboxamides: Synthesis, in vitro and in silico studies against Mycobacterium tuberculosis. Journal of Heterocyclic Chemistry, 58(11), pp.2140-2151, Journal of Heterocyclic Chemistry volume 58 number 11 p. 2140 2021 1943-5193
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Wiley Library Online Terms of Use Statement (https://onlinelibrary.wiley.com/terms-and-conditions)
- Rights
- Closed Access
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Collections
Khanye, David Setshaba (Associate Prof)
Lobb, Kevin Allan (Assoc Prof)
RU Department of Chemistry
RU Department of Pharmacy
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Arylquinolinecarboxamides.pdf | 943 KB | Adobe Acrobat PDF | View Details Download |