- Title
- Rational design and regioselective synthesis of conformationally restricted furan-derived ligands as potential anti-malarial agents
- Creator
- Mutorwa, Marius K, Nokalipa, Iviwe C, Tanner, Delia C, Blatch, Gregory L, Lobb, Kevin A, Klein, Rosalyn, Kaye, Perry T
- Subject
- To be catalogued
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/477650
- Identifier
- vital:78108
- Identifier
- xlink:href="https://doi.org/10.24820/ark.5550190.p011.281"
- Description
- Substituted 3-furanomethyl phosphate esters and their corresponding phosphoric acids have been prepared as conformationally restricted analogues of DOXP, the natural substrate for Plasmodium falciparum 1-deoxyD-xylulose-5-phosphate reductoisomerase (PfDXR), and fosmidomycin, an established inhibitor. Saturation Transfer Difference (STD) NMR analysis and in silico docking data suggest the potential of such compounds as PfDXR inhibitors.
- Format
- computer, online resource, application/pdf, 1 online resource (16 pages), pdf
- Publisher
- Archive for Organic Chemistry
- Language
- English
- Relation
- Organic Chemistry, Mutorwa, M.K., Nokalipa, I., Tanner, D.C., Blatch, G.L., Lobb, K.A., Klein, R. and Kayea, P.T., 2020. Rational design and regioselective synthesis of conformationally restricted furan-derived ligands as potential anti-malarial agents. Organic Chemistry, (part iii), pp. 136-151, Organic Chemistry volume 3 p. 136 2020 1090-2120
- Rights
- Publisher
- Rights
- This paper is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
- Rights
- Open Access
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- Visitors: 43
- Downloads: 6
Collections
Klein, Rosalyn (Assoc Prof)
Blatch, Gregory Lloyd (Prof)
Kaye, Perry T (Distinguished Fellow Emeritus Professor)
Lobb, Kevin Allan (Assoc Prof)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
RU Department of Biochemistry, Microbiology and Bioinformatics
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Rational design and regioselective synthesis of conformationally restricted furanderived ligands as potential anti-malarial agents.pdf | 1 MB | Adobe Acrobat PDF | View Details Download |