- Title
- Synthesis and anti-parasitic activity of C-benzylated (N-arylcarbamoyl) alkylphosphonate esters
- Creator
- Adeyemi, Christiana M, Isaacs, Michelle, Mnkandhla, Dumisani, Klein, Rosalyn, Hoppe, Heinrich C, Krause, Rui W M, Lobb, Kevin A, Kaye, Perry T
- Subject
- To be catalogued
- Date
- 2017
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/477661
- Identifier
- vital:78109
- Identifier
- xlink:href="https://doi.org/10.1016/j.tet.2017.01.045"
- Description
- Unexpected substituent-dependent regioselectivty challenges in the synthesis of C-benzylated (N-arylcarbamoyl) phosphonate esters have been resolved. The C-benzylated N-furfurylcarbamoyl derivative showed low micromolar PfLDH inhibition, while one of the C-benzylated N-arylcarbamoyl analogues was active against Nagana Trypanosoma brucei parasites which are responsible for African trypanosomiasis in cattle.
- Format
- computer, online resource, application/pdf, 1 online resource (7 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Tetrahedron, Adeyemi, C.M., Isaacs, M., Mnkandhla, D., Klein, R., Hoppe, H.C., Krause, R.W., Lobb, K.A. and Kaye, P.T., 2017. Synthesis and anti-parasitic activity of C-benzylated (N-arylcarbamoyl) alkylphosphonate esters. Tetrahedron, 73(13), pp.1661-1667, Tetrahedron volume 73 number 13 p. 1661 2017 0040-4020
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
- Hits: 18
- Visitors: 21
- Downloads: 5
Collections
Krause, Rui Werner Maçedo (Prof)
Klein, Rosalyn (Assoc Prof)
Isaacs, Michelle (Mrs)
RU Centre for Chemico- and Biomedicinal Research (CCBR)
Hoppe, Heinrich C (Prof)
Kaye, Perry T (Distinguished Fellow Emeritus Professor)
Lobb, Kevin Allan (Assoc Prof)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
RU Department of Biochemistry, Microbiology and Bioinformatics
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | Synthesis and anti-parasitic activity of C-benzylated (N-arylcarbamoyl) alkylphosphonate esters.pdf | 724 KB | Adobe Acrobat PDF | View Details |