Cancer stem cells in breast cancer and metastasis:
- Lawson, Jessica C, Blatch, Gregory L, Edkins, Adrienne L
- Authors: Lawson, Jessica C , Blatch, Gregory L , Edkins, Adrienne L
- Date: 2009
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165057 , vital:41205 , DOI: 10.1007/s10549-009-0524-9
- Description: The cancer stem cell theory poses that cancers develop from a subset of malignant cells that possess stem cell characteristics and has been proposed to account for the development of a variety of malignancies, including breast cancer. These cancer stem cells (CSC) possess characteristics of both stem cells and cancer cells, in that they have the properties of self-renewal, asymmetric cell division, resistance to apoptosis, independent growth, tumourigenicity and metastatic potential. A CSC origin for breast cancer can neatly explain both the heterogeneity of breast cancers and the relapse of the tumours after treatment. However, many reports on CSC in the breast are contradictory. There is variation with respect to how breast cancer stem cells should be identified, their characteristics and a possible lack of correlation between clinical outcome and breast cancer stem cell status of a tumour. These combined factors have made breast cancer stem cells a highly contentious issue. In this review, we highlight the progress in the analysis of cancer stem cells, with an emphasis on breast cancer.
- Full Text:
- Authors: Lawson, Jessica C , Blatch, Gregory L , Edkins, Adrienne L
- Date: 2009
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165057 , vital:41205 , DOI: 10.1007/s10549-009-0524-9
- Description: The cancer stem cell theory poses that cancers develop from a subset of malignant cells that possess stem cell characteristics and has been proposed to account for the development of a variety of malignancies, including breast cancer. These cancer stem cells (CSC) possess characteristics of both stem cells and cancer cells, in that they have the properties of self-renewal, asymmetric cell division, resistance to apoptosis, independent growth, tumourigenicity and metastatic potential. A CSC origin for breast cancer can neatly explain both the heterogeneity of breast cancers and the relapse of the tumours after treatment. However, many reports on CSC in the breast are contradictory. There is variation with respect to how breast cancer stem cells should be identified, their characteristics and a possible lack of correlation between clinical outcome and breast cancer stem cell status of a tumour. These combined factors have made breast cancer stem cells a highly contentious issue. In this review, we highlight the progress in the analysis of cancer stem cells, with an emphasis on breast cancer.
- Full Text:
SDF-1 and PDGF enhance αvβ5-mediated ERK activation and adhesion-independent growth of human pre-B cell lines:
- Acharya, Mridu, Edkins, Adrienne L, Ozanne, B, Cushley, W
- Authors: Acharya, Mridu , Edkins, Adrienne L , Ozanne, B , Cushley, W
- Date: 2009
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165044 , vital:41204 , DOI: 10.1038/leu.2009.126
- Description: CD23 acts through the αvβ5 integrin to promote growth of human pre-B cell lines in an adhesion-independent manner. αvβ5 is expressed on normal B-cell precursors in the bone marrow. Soluble CD23 (sCD23), short CD23-derived peptides containing the arg-lys-cys (RKC) motif recognized by αvβ5 and anti-αvβ5 monoclonal antibodies (MAbs) all sustain growth of pre-B cell lines. The chemokine stromal cell-derived factor-1 (SDF-1) regulates key processes during B-cell development. SDF-1 enhanced the growth-sustaining effect driven by ligation of αvβ5 with anti-αvβ5 MAb 15F-11, sCD23 or CD23-derived RKC-containing peptides. This effect was restricted to B-cell precursors and was specific to SDF-1.
- Full Text:
- Authors: Acharya, Mridu , Edkins, Adrienne L , Ozanne, B , Cushley, W
- Date: 2009
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165044 , vital:41204 , DOI: 10.1038/leu.2009.126
- Description: CD23 acts through the αvβ5 integrin to promote growth of human pre-B cell lines in an adhesion-independent manner. αvβ5 is expressed on normal B-cell precursors in the bone marrow. Soluble CD23 (sCD23), short CD23-derived peptides containing the arg-lys-cys (RKC) motif recognized by αvβ5 and anti-αvβ5 monoclonal antibodies (MAbs) all sustain growth of pre-B cell lines. The chemokine stromal cell-derived factor-1 (SDF-1) regulates key processes during B-cell development. SDF-1 enhanced the growth-sustaining effect driven by ligation of αvβ5 with anti-αvβ5 MAb 15F-11, sCD23 or CD23-derived RKC-containing peptides. This effect was restricted to B-cell precursors and was specific to SDF-1.
- Full Text:
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