- Title
- Synthesis and evaluation of substituted 4-(N-benzylamino)cinnamate esters as potential anti-cancer agents and HIV-1 integrase inhibitors
- Creator
- Faridoon, H, Edkins, Adrienne L, Isaacs, Michelle, Mnkandhla, Dumisani, Hoppe, Heinrich C, Kaye, Perry T
- Date
- 2016
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/66289
- Identifier
- vital:28929
- Identifier
- https://doi.org/10.1016/j.bmcl.2016.05.023
- Description
- publisher version
- Description
- Encouraging selectivity and low micromolar activity against HeLa cervical carcinoma (IC50 ⩾ 3.0 μM) and the aggressive MDA-MB-231 triple negative breast carcinoma (IC50 ⩾ 9.6 μM) cell lines has been exhibited by a number of readily accessible 4-(N-benzylamino)cinnamate esters. The potential of the ligands as HIV-1 integrase inhibitors has also been examined.
- Format
- 3 pages, pdf
- Language
- English
- Relation
- Bioorganic and Medicinal Chemistry Letters, Faridoon, H., Edkins, Adrienne L., Isaacs, Michelle, Hoppe, Heinrich C., Kaye, Perry T.(2016) Synthesis and evaluation of substituted 4-(N-benzylamino)cinnamate esters as potential anti-cancer agents and HIV-1 integrase inhibitors. Bioorganic and Medicinal Chemistry Letters, 26 (15), p. 3810-3812. ISSN: 0960-894X. https://doi.org/10.1016/j.bmcl.2016.05.023, Bioorganic and Medicinal Chemistry Letters volume 26 number 15 3810 3812 August 2016 0960-894X
- Rights
- Elsevier B.V.
- Rights
- Use of this resource is governed by the terms and conditions of the BioOrganic and Chemistry Letters Open Access Statement (https://www.elsevier.com/journals/bioorganic-and-medicinal-chemistry-letters/0960-894x/guide-for-authors)
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Collections
Edkins, Adrienne Lesley (Associate Prof)
Hoppe, Heinrich C (Prof)
Isaacs, Michelle (Mrs)
Kaye, Perry T (Distinguished Fellow Emeritus Professor)
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
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