- Title
- Nano-biomimetic drug delivery vehicles: Potential approaches for COVID-19 treatment
- Creator
- Witika, Bwalya A, Makoni, Pedzisai A, Mweetwa, Larry L, Ntemi, Pascal V, Chikukwa, Mellisa T R, Matafwali, Scott K, Mwila, Chiluba, Mudenda, Steward, Katandula, Jonathan, Walker, Roderick B
- Subject
- To be catalogued
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/183440
- Identifier
- vital:43991
- Identifier
- xlink:href="https://doi.org/10.3390/molecules25245952"
- Description
- The current COVID-19 pandemic has tested the resolve of the global community with more than 35 million infections worldwide and numbers increasing with no cure or vaccine available to date. Nanomedicines have an advantage of providing enhanced permeability and retention and have been extensively studied as targeted drug delivery strategies for the treatment of different disease. The role of monocytes, erythrocytes, thrombocytes, and macrophages in diseases, including infectious and inflammatory diseases, cancer, and atherosclerosis, are better understood and have resulted in improved strategies for targeting and in some instances mimicking these cell types to improve therapeutic outcomes. Consequently, these primary cell types can be exploited for the purposes of serving as a "Trojan horse" for targeted delivery to identified organs and sites of inflammation. State of the art and potential utilization of nanocarriers such as nanospheres/nanocapsules, nanocrystals, liposomes, solid lipid nanoparticles/nano-structured lipid carriers, dendrimers, and nanosponges for biomimicry and/or targeted delivery of bioactives to cells are reported herein and their potential use in the treatment of COVID-19 infections discussed. Physicochemical properties, viz., hydrophilicity, particle shape, surface charge, composition, concentration, the use of different target-specific ligands on the surface of carriers, and the impact on carrier efficacy and specificity are also discussed.
- Format
- computer, online resource, application/pdf, 1 online resource (20 pages), pdf
- Publisher
- MDPI
- Language
- English
- Relation
- Molecules, Witika, B.A., Makoni, P.A., Mweetwa, L.L., Ntemi, P.V., Chikukwa, M.T., Matafwali, S.K., Mwila, C., Mudenda, S., Katandula, J. and Walker, R.B., 2020. Nano-biomimetic drug delivery vehicles: potential approaches for COVID-19 treatment. Molecules, 25(24), p.5952, Molecules volume 25 number 24 p. 5952 2020 1420-3049
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the MDPI Open Access Statement (https://www.int-res.com/journals/terms-of-use/)
- Rights
- Open Access
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Collections
Walker, Roderick Bryan (Prof)
Makoni, Pedzisai A (Dr)
RU Department of Pharmacy
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | Nano-biomimetic drug delivery vehicles potential approaches for COVID-19 treatment.pdf | 1 MB | Adobe Acrobat PDF | View Details |