- Title
- A new indole alkaloid and other constituents from Monodora minor and Uvaria tanzaniae: their antitrypanosomal and antiplasmodial evaluation
- Creator
- Christopher, Robert, Mgani, Quintino A, Nyandoro, Stephen S, Rousseau, Amanda L, Isaacs, Michelle, Hoppe, Heinrich C
- Subject
- To be catalogued
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/429347
- Identifier
- vital:72603
- Identifier
- xlink:href="https://doi.org/10.1080/14786419.2019.1710705"
- Description
- Phytochemical investigation of the methanolic extract of Monodora minor Engl. and Diels (Annonaceae) stem bark yielded a new indole (E)-4-(1H-indol-5-yl)-but-3-en-2-one (1), a known indole 5-formyl-1H-indole (2) and an ubiquitous steroid sitosterol (3). The investigations of the methanolic extract of Uvaria tanzaniae Verdc. (Annonaceae) root bark yielded two previously reported C-benzylated dihydrochalcones namely uvaretin (4) and diuvaretin (5). Structures of the isolated compounds were elucidated based on NMR spectroscopy and high resolution electron ionization mass spectrometry (HR-EI-MS) data. All compounds were tested against Trypanosoma brucei brucei and Plasmodium falciparum. At a single concentration (20 μM) in the antitrypanosomal and antiplasmodial assays, compound 4 exhibited remarkable activities against T. brucei brucei and P. falciparum with percentage inhibition of 97.3% and 83.0% respectively, whereas compounds 1, 2, 3 and 5 were inactive. In a dose response antiplasmodial assay compound 4 exhibited moderate activity against P. falciparum with an IC50 value of 7.20 μM.
- Format
- computer, online resource, application/pdf, 1 online resource (8 pages), pdf
- Publisher
- Taylor and Francis
- Language
- English
- Relation
- Natural Product Research, Christopher, R., Mgani, Q.A., Nyandoro, S.S., Rousseau, A.L., Isaacs, M. and Hoppe, H.C. (2020) A new indole alkaloid and other constituents from Monodora minor and Uvaria tanzaniae: their antitrypanosomal and antiplasmodial evaluation. Natural Product Research. 10.1080/14786419.2019.1710705, Natural Product Research volume 35 number 20 p. 3470 2020 1478-6427
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Taylor and Francis Online Terms and Conditions Statement (https://www.tandfonline.com/terms-and-conditions)
- Rights
- Closed Access
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Collections
Hoppe, Heinrich C (Prof)
Isaacs, Michelle (Mrs)
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | A new indole alkaloid and other constituents from Monodora minor and Uvaria tanzaniae.pdf | 688 KB | Adobe Acrobat PDF | View Details |