- Title
- The In Silico Prediction of hotspot residues that contribute to the structural stability of subunit interfaces of a Picornavirus Capsid:
- Creator
- Upfold, Nicole, Ross, Caroline J, Tastan Bishop, Özlem, Knox, Caroline M
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/149970
- Identifier
- vital:38919
- Identifier
- https://doi.org/10.3390/v12040387
- Description
- The assembly of picornavirus capsids proceeds through the stepwise oligomerization of capsid protein subunits and depends on interactions between critical residues known as hotspots. Few studies have described the identification of hotspot residues at the protein subunit interfaces of the picornavirus capsid, some of which could represent novel drug targets. Using a combination of accessible web servers for hotspot prediction, we performed a comprehensive bioinformatic analysis of the hotspot residues at the intraprotomer, interprotomer and interpentamer interfaces of the Theiler’s murine encephalomyelitis virus (TMEV) capsid.
- Format
- 22 pages, pdf
- Language
- English
- Relation
- Viruses, Upfold, N., Ross, C., Tastan Bishop, Ö. and Knox, C., 2020. The In Silico Prediction of Hotspot Residues that Contribute to the Structural Stability of Subunit Interfaces of a Picornavirus Capsid. Viruses, 12(4), p.387., Viruses volume 12 number 4 p.387 March 2020 1999-4915
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the MDPI Open Access Statement (https://www.int-res.com/journals/terms-of-use/)
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Knox, Caroline (Prof)
RU Research Unit in Bioinformatics (RUBi)
Tastan Bishop, Ozlem (Prof)
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
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