- Title
- Enhanced Light-Driven Antimicrobial Activity of Cationic Poly (oxanorbornene) s by Phthalocyanine Incorporation into Polymer as Pendants
- Creator
- Ahmetali, Erem, Sen, Pinar, Süer, N Ceren, Aksu, Burak, Nyokong, Tebello, Eren, Tarik, Sener, Kasim M
- Subject
- To be catalogued
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/185976
- Identifier
- vital:44453
- Identifier
- xlink:href=" https://doi.org/10.1002/macp.202000386"
- Description
- Amphiphilic poly(oxanorbornene)s are promising synthetic polymers that mimic the structural properties and antimicrobial functions of naturally occurring antimicrobial peptides. Here, poly(oxanorbornene)s bearing pendant zinc(II) phthalocyanine and triphenyl(ethyl) phosphonium functionalities are synthesized by ring-opening metathesis polymerization (ROMP). Fluorescence, singlet oxygen and triplet quantum yields of polymers are measured in dimethyl sulfoxide and aqueous medium. The singlet oxygen quantum yields of copolymers with the highest triphenyl and triethyl phosphonium content are found to be 0.29 and 0.41, respectively. Then, antimicrobial activities of polymers against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) are investigated under both dark and light conditions. Synergistic effect of zinc(II) phthalocyanine and phosphonium-containing poly(oxanorbornene) is observed that the conjugate possessing the most triphenyl phosphonium side chains has the highest activity under light against both gram-positive and gram-negative bacterial strains after 80 min irradiation, reducing the survival of E. coli or S. aureus by 99.9999%. Hemolytic concentrations of the copolymers are found between 8 and 512 µg mL−1. Scanning electron microscopy (SEM) proves that the bacteria membrane deforms after contacting with the biocidal polymer.
- Format
- computer, online resource, application/pdf, 1 online resource (14 pages), pdf
- Publisher
- Wiley Library Online
- Language
- English
- Relation
- Macromolecular Chemistry and Physics, Ahmetali, E., Sen, P., Süer, N.C., Aksu, B., Nyokong, T., Eren, T. and Şener, M.K., 2020. Enhanced Light‐Driven Antimicrobial Activity of Cationic Poly (oxanorbornene) s by Phthalocyanine Incorporation into Polymer as Pendants. Macromolecular Chemistry and Physics, 221(24), p.2000386, Macromolecular Chemistry and Physics volume 221 number 24 p. 2000386 2020 1521-3935
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Wiley Library Online Terms of Use Statement (https://onlinelibrary.wiley.com/terms-and-conditions)
- Rights
- Closed Access
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Collections
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
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