- Title
- A simple quinoline-thiophene Schiff base turn-off chemosensor for Hg2+ detection
- Creator
- Musikavanhu, Brian, Muthusamy, Selvaraj, Zhu, Dongwei, Xue, Zhaoli, Yu, Qian, Chivumba, Choonzo N, Mack, John, Nyokong, Tebello, Wang, Shengjun, Zhao, Long
- Subject
- To be catalogued
- Date
- 2022
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/230362
- Identifier
- vital:49771
- Identifier
- xlink:href="https://doi.org/10.1016/j.saa.2021.120338"
- Description
- A new Schiff base probe (QT) consisting of 8-aminoquinoline (Q) and thiophene-2-carboxaldehyde (T) moieties has been synthesized. QT undergoes chelation-enhanced fluorescence quenching when exposed to Hg2+ due to coordination by the sulfur and nitrogen atoms of QT thus forming a facile “turn-off” sensor. The formation of the chelation complex was confirmed by UV–visible absorption and emission spectral measurements, 1H NMR titration and density functional theory calculations. These studies revealed that the probe exhibits high selectivity and sensitivity towards Hg2+ in the presence of other common metal ions. A low detection limit of 23.4 nM was determined and a Job plot confirmed a 2:1 stoichiometry between QT and Hg2+. The potential utility of QT as a sensor for Hg2+ ions in human HeLa cells was determined by confocal fluorescence microscopy, and its suitability for use in the field with environmental samples was tested with Whatman filter paper strips.
- Format
- computer, online resource, application/pdf, 1 online resource (9 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Musikavanhu, B., Muthusamy, S., Zhu, D., Xue, Z., Yu, Q., Chiyumba, C.N., Mack, J., Nyokong, T., Wang, S. and Zhao, L., 2022. A simple quinoline-thiophene Schiff base turn-off chemosensor for Hg2+ detection: spectroscopy, sensing properties and applications. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 264, p.120338, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy volume 264 p. 264 2022 1386-1425
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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Collections
Mack, John (Associate Prof)
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | A simple quinoline-thiophene Schiff.pdf | 896 KB | Adobe Acrobat PDF | View Details |