Cardiovascular disease and metabolic syndrome in health transition and evidence-based medicine: a perspective from Africa
- Authors: Longo-Mbenza, B
- Date: 2012
- Subjects: Cardiovascular Disease Cardiovascular systems -- Diseases -- Treatment
- Language: English
- Type: text , Lectures
- Identifier: http://hdl.handle.net/11260/1078 , vital:30578
- Description: The Cardiovascular Disease (CVD) pandemic worldwide presents a true challenge today with a high health burden that is only expected to rise. I address the causes and prevention of CVD, as well as CVD rehabilitation and physiology. As a member of the American Heart Association and European Society of cardiology, I practice under the level of evidence and the strength of recommendation of particular treatment options, as outlined in the tables below.
- Full Text:
- Date Issued: 2012
- Authors: Longo-Mbenza, B
- Date: 2012
- Subjects: Cardiovascular Disease Cardiovascular systems -- Diseases -- Treatment
- Language: English
- Type: text , Lectures
- Identifier: http://hdl.handle.net/11260/1078 , vital:30578
- Description: The Cardiovascular Disease (CVD) pandemic worldwide presents a true challenge today with a high health burden that is only expected to rise. I address the causes and prevention of CVD, as well as CVD rehabilitation and physiology. As a member of the American Heart Association and European Society of cardiology, I practice under the level of evidence and the strength of recommendation of particular treatment options, as outlined in the tables below.
- Full Text:
- Date Issued: 2012
Mildly elevated thyroid-stimulating hormone is associated with endothelial dysfunction and severe preeclampsia among pregnant women with insufficient iodine intake in Eastern Cape province, South Africa
- Businge, Charles Bitamazire, Longo-Mbenza, Benjamin, Kengne, Andre Pascal
- Authors: Businge, Charles Bitamazire , Longo-Mbenza, Benjamin , Kengne, Andre Pascal
- Date: 2021
- Subjects: Preeclampsia Iodine deficiency diseases Endothelial cells Article
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/6908 , vital:52565 , xlink:href="https://10.1080/07853890.2021.1947520"
- Description: Background Preeclampsia and hypothyroidism are associated with endothelial dysfunction. Iodine deficiency is a risk factor for subclinical hypothyroidism in pregnancy. However, there is a paucity of data on the relationship between iodine nutrition state in pregnancy, the degree of endothelial dysfunction, and the risk of preeclampsia. Methods Ninety-five normotensive pregnant women, 50 women with preeclampsia with no severe features, and 50 women with severe preeclampsia were enrolled into the current study from the maternity units of Nelson Mandela Academic Hospital and Mthatha Regional Hospitals in Eastern Cape Province, South Africa. Urinary iodine concentration (UIC), serum markers of thyroid function, aortic augmentation index, and pulse wave velocity (PWV) were compared. Results Median UIC was 167.5, 127.7, and 88.5 µg/L, respectively for normotensive pregnant women, those with preeclampsia and severe preeclampsia (p = .150). Participants with severe preeclampsia had significantly higher median thyroid-stimulating hormone (TSH) and oxidized LDL than normotensive and preeclamptic women without severe features (respectively 3.0, 2.3, and 2.3 IU/L; 1.2, 1.0, and 1.0 IU/L, p less .05). The median Aortic augmentation index was 7.5, 19.0, and 21.0 (p less .001), and the pulse wave velocity 5.1, 5.7, and 6.3, respectively for normotensive, preeclampsia, and severe preeclampsia participants (both p less .001). In linear regressions, TSH, age, and hypertensive disease were independent predictors of elevated PWV. Conclusion Upper normal-range TSH levels in women with severe preeclampsia were associated with markers of endothelial dysfunction. The low UIC and trend towards the elevation of thyroglobulin suggest that inadequate iodine intake may have increased TSH levels and indirectly caused endothelial dysfunction. Keywords: Preeclampsia, Iodine deficiency, Elevated thyroid-stimulating hormone, Pulse wave velocity, Endothelial dysfunction
- Full Text:
- Date Issued: 2021
- Authors: Businge, Charles Bitamazire , Longo-Mbenza, Benjamin , Kengne, Andre Pascal
- Date: 2021
- Subjects: Preeclampsia Iodine deficiency diseases Endothelial cells Article
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/6908 , vital:52565 , xlink:href="https://10.1080/07853890.2021.1947520"
- Description: Background Preeclampsia and hypothyroidism are associated with endothelial dysfunction. Iodine deficiency is a risk factor for subclinical hypothyroidism in pregnancy. However, there is a paucity of data on the relationship between iodine nutrition state in pregnancy, the degree of endothelial dysfunction, and the risk of preeclampsia. Methods Ninety-five normotensive pregnant women, 50 women with preeclampsia with no severe features, and 50 women with severe preeclampsia were enrolled into the current study from the maternity units of Nelson Mandela Academic Hospital and Mthatha Regional Hospitals in Eastern Cape Province, South Africa. Urinary iodine concentration (UIC), serum markers of thyroid function, aortic augmentation index, and pulse wave velocity (PWV) were compared. Results Median UIC was 167.5, 127.7, and 88.5 µg/L, respectively for normotensive pregnant women, those with preeclampsia and severe preeclampsia (p = .150). Participants with severe preeclampsia had significantly higher median thyroid-stimulating hormone (TSH) and oxidized LDL than normotensive and preeclamptic women without severe features (respectively 3.0, 2.3, and 2.3 IU/L; 1.2, 1.0, and 1.0 IU/L, p less .05). The median Aortic augmentation index was 7.5, 19.0, and 21.0 (p less .001), and the pulse wave velocity 5.1, 5.7, and 6.3, respectively for normotensive, preeclampsia, and severe preeclampsia participants (both p less .001). In linear regressions, TSH, age, and hypertensive disease were independent predictors of elevated PWV. Conclusion Upper normal-range TSH levels in women with severe preeclampsia were associated with markers of endothelial dysfunction. The low UIC and trend towards the elevation of thyroglobulin suggest that inadequate iodine intake may have increased TSH levels and indirectly caused endothelial dysfunction. Keywords: Preeclampsia, Iodine deficiency, Elevated thyroid-stimulating hormone, Pulse wave velocity, Endothelial dysfunction
- Full Text:
- Date Issued: 2021
Insufficient iodine nutrition status and the risk of pre-eclampsia: a systemic review and meta-analysis
- Charles Bitamazire Businge, Anthony Usenbo, Benjamin Longo-Mbenza, AP Kengne
- Authors: Charles Bitamazire Businge , Anthony Usenbo , Benjamin Longo-Mbenza , AP Kengne
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3876 , vital:43961
- Full Text:
- Authors: Charles Bitamazire Businge , Anthony Usenbo , Benjamin Longo-Mbenza , AP Kengne
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3876 , vital:43961
- Full Text:
Diagnostic performance of several biomarkers for identification of cases of non-communicable diseases among Central Africans
- Charles Bitamazire Businge, Benjamin Longo-Mbenza, Oladele Vincent Adeniyi, Moise Mvitu Muaka, Georges Mvumbi Lelo, Mireille Solange Nganga Nkanga, Jean-Marie Kavembe, Baudoin Buassa-bu-Tsumbu, Jean-Rene’ M’buyamba Kabangu, Daniel Ter Goon
- Authors: Charles Bitamazire Businge , Benjamin Longo-Mbenza , Oladele Vincent Adeniyi , Moise Mvitu Muaka , Georges Mvumbi Lelo , Mireille Solange Nganga Nkanga , Jean-Marie Kavembe , Baudoin Buassa-bu-Tsumbu , Jean-Rene’ M’buyamba Kabangu , Daniel Ter Goon
- Date: 2018
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4845 , vital:44292
- Full Text:
- Authors: Charles Bitamazire Businge , Benjamin Longo-Mbenza , Oladele Vincent Adeniyi , Moise Mvitu Muaka , Georges Mvumbi Lelo , Mireille Solange Nganga Nkanga , Jean-Marie Kavembe , Baudoin Buassa-bu-Tsumbu , Jean-Rene’ M’buyamba Kabangu , Daniel Ter Goon
- Date: 2018
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4845 , vital:44292
- Full Text:
Iodine nutrition status in Africa: Potentially high prevalence of iodine deficiency in pregnancy even in countries classified as iodine sufficient
- Charles Bitamazire Businge, Benjamin Longo-Mbenza, Andre Pascal Kengne
- Authors: Charles Bitamazire Businge , Benjamin Longo-Mbenza , Andre Pascal Kengne
- Date: 03-8-2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3377 , vital:43336 , https://www.cambridge.org/core/journals/public-health-nutrition/article/iodine-nutrition-status-in-africa-potentially-high-prevalence-of-iodine-deficiency-in-pregnancy-even-in-countries-classified-as-iodine-sufficient/B3DCB06E75CDDD8EAD410BE090198BA4
- Description: Objective: To assess the burden of iodine deficiency in pregnancy in Africa using estimated pregnancy median urinary iodine concentration (pMUIC). Design: pMUIC for each African country was estimated using a regression equation derived by correlating the school-age children (SAC) median UIC (mUIC) and pMUIC from countries around the globe, and the SAC mUIC data for African countries obtained from the Iodine Global Network (IGN) 2017 and 2019 Score cards. Setting: Iodine deficiency was endemic in many African countries before the introduction of iodine fortification, mainly through universal salt iodisation programmes about 25 years ago. There is a scarcity of data on the level of iodine nutrition in pregnancy in Africa. Women living in settings with pMUIC below 150 μg/l are at risk of iodine deficiency-related pregnancy complications. Participants: Fifty of the fifty-five African countries that had data on iodine nutrition status. Results: A cut-off school age mUIC ≤ 175 μg/l is correlated with insufficient iodine intake in pregnancy (pregnancy mUIC ≤ 150 μg/l). Twenty-two African countries had SAC mUIC less than 175 μg/l, which correlated with insufficient iodine intake during pregnancy (pMUIC less than 150 μg/l). However, nine of these twenty-two countries had adequate iodine intake based on SAC mUIC. Conclusions: There is likely a high prevalence of insufficient iodine intake in pregnancy, including in some African countries classified as having adequate iodine intake in the general population. A SAC mUIC ≤ 175 μ
- Full Text:
- Date Issued: 03-8-2020
- Authors: Charles Bitamazire Businge , Benjamin Longo-Mbenza , Andre Pascal Kengne
- Date: 03-8-2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3377 , vital:43336 , https://www.cambridge.org/core/journals/public-health-nutrition/article/iodine-nutrition-status-in-africa-potentially-high-prevalence-of-iodine-deficiency-in-pregnancy-even-in-countries-classified-as-iodine-sufficient/B3DCB06E75CDDD8EAD410BE090198BA4
- Description: Objective: To assess the burden of iodine deficiency in pregnancy in Africa using estimated pregnancy median urinary iodine concentration (pMUIC). Design: pMUIC for each African country was estimated using a regression equation derived by correlating the school-age children (SAC) median UIC (mUIC) and pMUIC from countries around the globe, and the SAC mUIC data for African countries obtained from the Iodine Global Network (IGN) 2017 and 2019 Score cards. Setting: Iodine deficiency was endemic in many African countries before the introduction of iodine fortification, mainly through universal salt iodisation programmes about 25 years ago. There is a scarcity of data on the level of iodine nutrition in pregnancy in Africa. Women living in settings with pMUIC below 150 μg/l are at risk of iodine deficiency-related pregnancy complications. Participants: Fifty of the fifty-five African countries that had data on iodine nutrition status. Results: A cut-off school age mUIC ≤ 175 μg/l is correlated with insufficient iodine intake in pregnancy (pregnancy mUIC ≤ 150 μg/l). Twenty-two African countries had SAC mUIC less than 175 μg/l, which correlated with insufficient iodine intake during pregnancy (pMUIC less than 150 μg/l). However, nine of these twenty-two countries had adequate iodine intake based on SAC mUIC. Conclusions: There is likely a high prevalence of insufficient iodine intake in pregnancy, including in some African countries classified as having adequate iodine intake in the general population. A SAC mUIC ≤ 175 μ
- Full Text:
- Date Issued: 03-8-2020
Insufficient iodine nutrition status and the risk of pre-eclampsia: a protocol for systematic review and meta-analysis
- Charles Bitamazire Businge, Namhla Madini, Benjamin Longo-Mbenza, A P Kengne
- Authors: Charles Bitamazire Businge , Namhla Madini , Benjamin Longo-Mbenza , A P Kengne
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4602 , vital:44141
- Full Text:
- Authors: Charles Bitamazire Businge , Namhla Madini , Benjamin Longo-Mbenza , A P Kengne
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4602 , vital:44141
- Full Text:
Ageing, exposure to pollution, and interactions between climate change and local seasons as oxidant conditions predicting incident hematologic malignancy at KINSHASA University clinics, Democratic Republic of CONGO (DRC)
- Mireille Solange Nganga Nkanga, Benjamin Longo-Mbenza, Oladele Vincent Adeniyi, Jacques Bikaula Ngwidiwo, Antoine Lufimbo Katawandja, Paul Roger Beia Kazadi, Alain Nganga Nzonzila
- Authors: Mireille Solange Nganga Nkanga , Benjamin Longo-Mbenza , Oladele Vincent Adeniyi , Jacques Bikaula Ngwidiwo , Antoine Lufimbo Katawandja , Paul Roger Beia Kazadi , Alain Nganga Nzonzila
- Date: 2017
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/3988 , vital:43980
- Full Text:
- Authors: Mireille Solange Nganga Nkanga , Benjamin Longo-Mbenza , Oladele Vincent Adeniyi , Jacques Bikaula Ngwidiwo , Antoine Lufimbo Katawandja , Paul Roger Beia Kazadi , Alain Nganga Nzonzila
- Date: 2017
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/3988 , vital:43980
- Full Text:
KASWA Researcher Profile and List of Publications .pdf
- Authors: Kaswa, Ramprakash
- Identifier: http://hdl.handle.net/11260/4783 , vital:44253
- Description:
Expertise:
Clinical research in field of HIV, TB, Women’s health and communicable disease; Clinical research data analysis both quantitative and Qualitative
- Full Text:
- Authors: Kaswa, Ramprakash
- Identifier: http://hdl.handle.net/11260/4783 , vital:44253
- Description:
Expertise:
Clinical research in field of HIV, TB, Women’s health and communicable disease; Clinical research data analysis both quantitative and Qualitative
- Full Text:
The Role of T Helper 17 (Th17) and Regulatory T Cells (Treg) in the Pathogenesis of Vulvovaginal Candidiasis among HIV-Infected Women
- Teke Apalata, Benjamin Longo-Mbenza
- Authors: Teke Apalata , Benjamin Longo-Mbenza
- Date: 2020
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4363 , vital:44109
- Full Text:
- Authors: Teke Apalata , Benjamin Longo-Mbenza
- Date: 2020
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4363 , vital:44109
- Full Text:
Insufficient iodine nutrition status and the risk of pre-eclampsia: a protocol for systematic review and meta-analysis
- Authors: Charles Bitamazire Businge
- Date: 2017
- Language: English
- Type: Journal
- Identifier: http://hdl.handle.net/11260/5729 , vital:44637
- Full Text:
- Authors: Charles Bitamazire Businge
- Date: 2017
- Language: English
- Type: Journal
- Identifier: http://hdl.handle.net/11260/5729 , vital:44637
- Full Text:
The prevalence of insufficient iodine intake in pregnancy in Africa: protocol for a systematic review and meta-analysis
- Businge, Charles Bitamazire, Longo-Mbenza , Benjamin, Kengne, Andre Pascal
- Authors: Businge, Charles Bitamazire , Longo-Mbenza , Benjamin , Kengne, Andre Pascal
- Date: 2019
- Subjects: Africa , Iodine , Pregnancy
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/5882 , vital:44662 , https://DOI:10.1186/s13643-019-1092-7
- Description: Background: Insufficient iodine intake in pregnancy is associated with many adverse pregnancy outcomes. About 90% of African countries are at risk of iodine deficiency due to poor soils and dietary goitrogens. Pregnancy predisposes to insufficient iodine nutrition secondary to increased physiological demand and increased renal loss. Iodine deficiency is re-emerging in countries thought to be replete with pregnant women being the most affected. This review seeks to identify the degree of iodine nutrition in pregnancy on the entire African continent before and after the implementation of national iodization programmes. Methods: A systematic search of published literature will be conducted for observational studies that directly determined the prevalence of insufficient iodine intake among pregnant women in Africa. Electronic databases and grey literature will be searched for baseline data before the implementation of population-based iodine supplementation and for follow-up data up to December 2018. Screening of identified articles and data extraction will be conducted independently by two investigators. Risk of bias and methodological quality of the included studies will be assessed using a risk of bias tool. Appropriate meta-analytic techniques will be used to pool prevalence estimates from studies with similar features, overall and by major characteristics including the region of the study, time period (before and after implementation of iodization programmes), sample size and age. Heterogeneity of the estimates across studies will be quantified and publication bias investigated. This protocol is reported according to Preferred Reporting Items for Systematic reviews and Meta-Analysis protocols (PRISMA-P) 2015 guidelines. Discussion: This review will help ascertain the impact of national iodization programmes on the iodine nutrition status in pregnancy in Africa and advise policy on the necessity for monitoring and mitigating iodine deficiency in pregnancy in Africa. This review is part of a thesis that will be submitted to the Faculty of Health Sciences, University of Cape Town, for the award of a PhD in Medicine whose protocol has been granted ethics approval (UCT HREC 135/2018). In addition, the results will be published in a peer-reviewed journal. Systematic review registration: PROSPERO CRD42018099434 Keywords: Iodine, Insufficiency, Pregnancy, Africa
- Full Text:
- Date Issued: 2019
- Authors: Businge, Charles Bitamazire , Longo-Mbenza , Benjamin , Kengne, Andre Pascal
- Date: 2019
- Subjects: Africa , Iodine , Pregnancy
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/5882 , vital:44662 , https://DOI:10.1186/s13643-019-1092-7
- Description: Background: Insufficient iodine intake in pregnancy is associated with many adverse pregnancy outcomes. About 90% of African countries are at risk of iodine deficiency due to poor soils and dietary goitrogens. Pregnancy predisposes to insufficient iodine nutrition secondary to increased physiological demand and increased renal loss. Iodine deficiency is re-emerging in countries thought to be replete with pregnant women being the most affected. This review seeks to identify the degree of iodine nutrition in pregnancy on the entire African continent before and after the implementation of national iodization programmes. Methods: A systematic search of published literature will be conducted for observational studies that directly determined the prevalence of insufficient iodine intake among pregnant women in Africa. Electronic databases and grey literature will be searched for baseline data before the implementation of population-based iodine supplementation and for follow-up data up to December 2018. Screening of identified articles and data extraction will be conducted independently by two investigators. Risk of bias and methodological quality of the included studies will be assessed using a risk of bias tool. Appropriate meta-analytic techniques will be used to pool prevalence estimates from studies with similar features, overall and by major characteristics including the region of the study, time period (before and after implementation of iodization programmes), sample size and age. Heterogeneity of the estimates across studies will be quantified and publication bias investigated. This protocol is reported according to Preferred Reporting Items for Systematic reviews and Meta-Analysis protocols (PRISMA-P) 2015 guidelines. Discussion: This review will help ascertain the impact of national iodization programmes on the iodine nutrition status in pregnancy in Africa and advise policy on the necessity for monitoring and mitigating iodine deficiency in pregnancy in Africa. This review is part of a thesis that will be submitted to the Faculty of Health Sciences, University of Cape Town, for the award of a PhD in Medicine whose protocol has been granted ethics approval (UCT HREC 135/2018). In addition, the results will be published in a peer-reviewed journal. Systematic review registration: PROSPERO CRD42018099434 Keywords: Iodine, Insufficiency, Pregnancy, Africa
- Full Text:
- Date Issued: 2019
The prevalence of insufficient iodine intake in pregnancy in Africa: Protocol for a systematic review and meta-analysis
- Charles Bitamazire Businge, Benjamin Longo-Mbenza, Andre Pascal Kengne
- Authors: Charles Bitamazire Businge , Benjamin Longo-Mbenza , Andre Pascal Kengne
- Date: 22-8-2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3387 , vital:43338 , https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-019-1092-7#citeas
- Description: Background: Insufficient iodine intake in pregnancy is associated with many adverse pregnancy outcomes. About 90% of African countries are at risk of iodine deficiency due to poor soils and dietary goitrogens. Pregnancy predisposes to insufficient iodine nutrition secondary to increased physiological demand and increased renal loss. Iodine deficiency is re-emerging in countries thought to be replete with pregnant women being the most affected. This review seeks to identify the degree of iodine nutrition in pregnancy on the entire African continent before and after the implementation of national iodization programmes. Methods: A systematic search of published literature will be conducted for observational studies that directly determined the prevalence of insufficient iodine intake among pregnant women in Africa. Electronic databases and grey literature will be searched for baseline data before the implementation of population-based iodine supplementation and for follow-up data up to December 2018. Screening of identified articles and data extraction will be conducted independently by two investigators. Risk of bias and methodological quality of the included studies will be assessed using a risk of bias tool. Appropriate meta-analytic techniques will be used to pool prevalence estimates from studies with similar features, overall and by major characteristics including the region of the study, time period (before and after implementation of iodization programmes), sample size and age. Heterogeneity of the estimates across studies will be quantified and publication bias investigated. This protocol is reported according to Preferred Reporting Items for Systematic reviews and Meta-Analysis protocols (PRISMA-P) 2015 guidelines. Discussion This review will help ascertain the impact of national iodization programmes on the iodine nutrition status in pregnancy in Africa and advise policy on the necessity for monitoring and mitigating iodine deficiency in pregnancy in Africa. This review is part of a thesis that will be submitted to the Faculty of Health Sciences, University of Cape Town, for the award of a PhD in Medicine whose protocol has been granted ethics approval (UCT HREC 135/2018). In addition, the results will be published in a peer-reviewed journal.
- Full Text:
- Date Issued: 22-8-2019
- Authors: Charles Bitamazire Businge , Benjamin Longo-Mbenza , Andre Pascal Kengne
- Date: 22-8-2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3387 , vital:43338 , https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-019-1092-7#citeas
- Description: Background: Insufficient iodine intake in pregnancy is associated with many adverse pregnancy outcomes. About 90% of African countries are at risk of iodine deficiency due to poor soils and dietary goitrogens. Pregnancy predisposes to insufficient iodine nutrition secondary to increased physiological demand and increased renal loss. Iodine deficiency is re-emerging in countries thought to be replete with pregnant women being the most affected. This review seeks to identify the degree of iodine nutrition in pregnancy on the entire African continent before and after the implementation of national iodization programmes. Methods: A systematic search of published literature will be conducted for observational studies that directly determined the prevalence of insufficient iodine intake among pregnant women in Africa. Electronic databases and grey literature will be searched for baseline data before the implementation of population-based iodine supplementation and for follow-up data up to December 2018. Screening of identified articles and data extraction will be conducted independently by two investigators. Risk of bias and methodological quality of the included studies will be assessed using a risk of bias tool. Appropriate meta-analytic techniques will be used to pool prevalence estimates from studies with similar features, overall and by major characteristics including the region of the study, time period (before and after implementation of iodization programmes), sample size and age. Heterogeneity of the estimates across studies will be quantified and publication bias investigated. This protocol is reported according to Preferred Reporting Items for Systematic reviews and Meta-Analysis protocols (PRISMA-P) 2015 guidelines. Discussion This review will help ascertain the impact of national iodization programmes on the iodine nutrition status in pregnancy in Africa and advise policy on the necessity for monitoring and mitigating iodine deficiency in pregnancy in Africa. This review is part of a thesis that will be submitted to the Faculty of Health Sciences, University of Cape Town, for the award of a PhD in Medicine whose protocol has been granted ethics approval (UCT HREC 135/2018). In addition, the results will be published in a peer-reviewed journal.
- Full Text:
- Date Issued: 22-8-2019
Beliefs, Attitudes, Practices, Response to Interventions and Therapeutic Education of Obese and Normal Weight Type 2 Diabetes Mellitus Patients attending the Diabetic Clinic in Nelson Mandela Academic Hospital, Mthatha
- Authors: Odufu Alexander Abiodun
- Date: 2014
- Language: English
- Type: Masters
- Identifier: http://hdl.handle.net/11260/2854 , vital:42965 , Type 2 diabetes, belief, attitudes, practices, responses to intervention, therapeutic education
- Description: ABSTRACT INTRODUCTION: Education is the cornerstone of diabetes care. Because of lack of awareness, most patients suffer from diabetes complications. This study was conducted to determine the knowledge, attitude, practices and responses to interventions and therapeutic education of obese and normal weight type 2 diabetes mellitus patients. OBJECTIVES: The objectives of the study were: to determine the knowledge, beliefs, attitudes and practices among patients with T2DM; to estimate the proportions of uncontrolled blood glucose, poor quality of life, and no adherence to medications and diet among patients with T2DM; to explore food choices and nutrition practices and behavior related to T2DM; and to develop from responses, educational programs towards self and health professional management. Methods: This descriptive study included two hundred T2DM. A modified version of the Diabetes knowledge, attitude and practice (KAP) questionnaires were used for data collection. The participants were recruited using convenience sampling technique and all data collected was analyzed using SPSS version 18. The patient‟s knowledge, attitudes and practice about the disease, the proportion of uncontrolled blood glucose and no adherence to medication and diet, nutrition practices and behavior related to T2DM were the main outcome measures. Results: The mean age of the patients were 49.0±16.6 years for men and 48.2±15.8 years for females with the male to female ratio being 1:1. The population was formed by adults and elderly adults, who were between 18 and 80 years of age. Most were obese (43.0%); married (50.5%) and overweight (27.7%). Patients‟ awareness about diabetes was high. The overall knowledge on the etiology and features of T2DM was good. Answers for glycemic control, risk factors and complications were very good. Awareness about eye and renal complications was also high. A majority also noted eye problems as the complication of DM yet only 69% have visited an ophthalmologist. More than half of the sample population correctly answers questions regarding dietary requirements in diabetes.80% of the patients responded that alcohol is not good for a diabetic, that losing weight can prevent diabetic from getting worse and that smoking can worsen diabetes. 20% of the population does not know that the above mentioned factors are important in the management of their condition. The percentage of uncontrolled blood sugar and HbA1c among T2DM residing in Mthatha was good as 80% of the patients have their previous and current blood sugar level and HbA1c as normal. Conclusions: The knowledge, attitude and practice scores were high in most areas of diabetes care. However, the majority of the patients were obese emphasizing the need for additional educational efforts in life style modification.
- Full Text:
- Authors: Odufu Alexander Abiodun
- Date: 2014
- Language: English
- Type: Masters
- Identifier: http://hdl.handle.net/11260/2854 , vital:42965 , Type 2 diabetes, belief, attitudes, practices, responses to intervention, therapeutic education
- Description: ABSTRACT INTRODUCTION: Education is the cornerstone of diabetes care. Because of lack of awareness, most patients suffer from diabetes complications. This study was conducted to determine the knowledge, attitude, practices and responses to interventions and therapeutic education of obese and normal weight type 2 diabetes mellitus patients. OBJECTIVES: The objectives of the study were: to determine the knowledge, beliefs, attitudes and practices among patients with T2DM; to estimate the proportions of uncontrolled blood glucose, poor quality of life, and no adherence to medications and diet among patients with T2DM; to explore food choices and nutrition practices and behavior related to T2DM; and to develop from responses, educational programs towards self and health professional management. Methods: This descriptive study included two hundred T2DM. A modified version of the Diabetes knowledge, attitude and practice (KAP) questionnaires were used for data collection. The participants were recruited using convenience sampling technique and all data collected was analyzed using SPSS version 18. The patient‟s knowledge, attitudes and practice about the disease, the proportion of uncontrolled blood glucose and no adherence to medication and diet, nutrition practices and behavior related to T2DM were the main outcome measures. Results: The mean age of the patients were 49.0±16.6 years for men and 48.2±15.8 years for females with the male to female ratio being 1:1. The population was formed by adults and elderly adults, who were between 18 and 80 years of age. Most were obese (43.0%); married (50.5%) and overweight (27.7%). Patients‟ awareness about diabetes was high. The overall knowledge on the etiology and features of T2DM was good. Answers for glycemic control, risk factors and complications were very good. Awareness about eye and renal complications was also high. A majority also noted eye problems as the complication of DM yet only 69% have visited an ophthalmologist. More than half of the sample population correctly answers questions regarding dietary requirements in diabetes.80% of the patients responded that alcohol is not good for a diabetic, that losing weight can prevent diabetic from getting worse and that smoking can worsen diabetes. 20% of the population does not know that the above mentioned factors are important in the management of their condition. The percentage of uncontrolled blood sugar and HbA1c among T2DM residing in Mthatha was good as 80% of the patients have their previous and current blood sugar level and HbA1c as normal. Conclusions: The knowledge, attitude and practice scores were high in most areas of diabetes care. However, the majority of the patients were obese emphasizing the need for additional educational efforts in life style modification.
- Full Text:
Predictors of recovery in moderate to severe traumatic brain injury
- Kadhaya David Muballe, Constance R. Sewani-Rusike, Benjamin Longo-Mbenza, Jehu Iputo
- Authors: Kadhaya David Muballe , Constance R. Sewani-Rusike , Benjamin Longo-Mbenza , Jehu Iputo
- Date: 2019
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/3694 , vital:43927
- Full Text:
- Authors: Kadhaya David Muballe , Constance R. Sewani-Rusike , Benjamin Longo-Mbenza , Jehu Iputo
- Date: 2019
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/3694 , vital:43927
- Full Text:
Impacts of supplemental irrigation as a climate change adaptation strategy for maize production: a case of the Eastern Cape Province of South Africa S Ndhleve1*, MDV Nakin1 and B Longo-Mbenza1
- S Ndhleve, MDV Nakin, B Longo-Mbenza
- Authors: S Ndhleve , MDV Nakin , B Longo-Mbenza
- Date: 2017
- Language: English
- Type: Research
- Identifier: http://hdl.handle.net/11260/5635 , vital:44618
- Full Text:
- Authors: S Ndhleve , MDV Nakin , B Longo-Mbenza
- Date: 2017
- Language: English
- Type: Research
- Identifier: http://hdl.handle.net/11260/5635 , vital:44618
- Full Text:
The prevalence of insufficient iodine intake in pregnancy in Africa: protocol for a systematic review and meta-analysis
- Charles Bitamazire Businge, Benjamin Longo-Mbenza, Andre Pascal Kengne
- Authors: Charles Bitamazire Businge , Benjamin Longo-Mbenza , Andre Pascal Kengne
- Date: 2019
- Language: English
- Type: Journal article , pdf
- Identifier: http://hdl.handle.net/11260/4379 , vital:44112
- Full Text:
- Authors: Charles Bitamazire Businge , Benjamin Longo-Mbenza , Andre Pascal Kengne
- Date: 2019
- Language: English
- Type: Journal article , pdf
- Identifier: http://hdl.handle.net/11260/4379 , vital:44112
- Full Text:
The prevalence of insufficient iodine intake in pregnancy in Africa: protocol for a systematic review and meta-analysis
- Charles Bitamazire Businge, Benjamin Longo-Mbenza, Andre Pascal Kengne
- Authors: Charles Bitamazire Businge , Benjamin Longo-Mbenza , Andre Pascal Kengne
- Date: 2019
- Language: English
- Type: Journal article , pdf
- Identifier: http://hdl.handle.net/11260/4386 , vital:44111
- Full Text:
- Authors: Charles Bitamazire Businge , Benjamin Longo-Mbenza , Andre Pascal Kengne
- Date: 2019
- Language: English
- Type: Journal article , pdf
- Identifier: http://hdl.handle.net/11260/4386 , vital:44111
- Full Text:
Cross-sectional study of diabetes kidney disease in the Eastern Cape, South Africa
- Oladele Vincent Adeniyi, Eyitayo Omolara Owolabi
- Authors: Oladele Vincent Adeniyi , Eyitayo Omolara Owolabi
- Date: 2020
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4569 , vital:44134
- Full Text:
- Authors: Oladele Vincent Adeniyi , Eyitayo Omolara Owolabi
- Date: 2020
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4569 , vital:44134
- Full Text:
Cross-sectional study of diabetes kidney disease in the Eastern Cape, South Africa
- Oladele Vincent Adeniyi, Eyitayo Omolara Owolabi
- Authors: Oladele Vincent Adeniyi , Eyitayo Omolara Owolabi
- Date: 2020
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3856 , vital:43958
- Full Text:
- Authors: Oladele Vincent Adeniyi , Eyitayo Omolara Owolabi
- Date: 2020
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3856 , vital:43958
- Full Text:
A Review of Arterial Stiffness and HIV Infection in Adult Africans
- Awotedu, Kofoworola Olajire, Iputo, Jehu
- Authors: Awotedu, Kofoworola Olajire , Iputo, Jehu
- Date: 09-06-2016
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3484 , vital:43615 , https://www.hilarispublisher.com/open-access/a-review-of-arterial-stiffness-and-hiv-infection-in-adult-africans-2167-1095-1000221.pdf
- Description: Aim: To review the impact of the human immunodeficiency virus and antiretroviral therapy on the vasculature. Objectives: This review seeks to identify the burden which the human immunodeficiency virus and antiretroviral therapy have on the vasculature. Method: Medline/PubMed and Google scholar were searched. There were over 100 publications reviewed. Some people who worked in similar fields were also contacted. The present review summarized current understanding of Human immunodeficiency virus, antiretroviral therapy and effect on the vasculature such as arterial stiffness. Atherosclerosis, endothelial dysfunction, the strengths and weaknesses of current testing strategies, and their potential applications in clinical research and patient care. The association of inflammatory biomarkers, blood pressure and ageing with arterial stiffness were also reviewed. Conclusion: Available literature shows that HIV and antiretroviral agents have a great impact on the vasculature and its progression.
- Full Text:
- Date Issued: 09-06-2016
- Authors: Awotedu, Kofoworola Olajire , Iputo, Jehu
- Date: 09-06-2016
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3484 , vital:43615 , https://www.hilarispublisher.com/open-access/a-review-of-arterial-stiffness-and-hiv-infection-in-adult-africans-2167-1095-1000221.pdf
- Description: Aim: To review the impact of the human immunodeficiency virus and antiretroviral therapy on the vasculature. Objectives: This review seeks to identify the burden which the human immunodeficiency virus and antiretroviral therapy have on the vasculature. Method: Medline/PubMed and Google scholar were searched. There were over 100 publications reviewed. Some people who worked in similar fields were also contacted. The present review summarized current understanding of Human immunodeficiency virus, antiretroviral therapy and effect on the vasculature such as arterial stiffness. Atherosclerosis, endothelial dysfunction, the strengths and weaknesses of current testing strategies, and their potential applications in clinical research and patient care. The association of inflammatory biomarkers, blood pressure and ageing with arterial stiffness were also reviewed. Conclusion: Available literature shows that HIV and antiretroviral agents have a great impact on the vasculature and its progression.
- Full Text:
- Date Issued: 09-06-2016