- Title
- An in vitro investigation of novel quinolone derivatives on selected pharmacological targets for diabetes mellitus and associated complications
- Creator
- Ayodele, Omobolanle Opeyemi
- ThesisAdvisor
- Sibiya, Ntethelelo
- ThesisAdvisor
- Khanye, Setshaba
- ThesisAdvisor
- Mothibe, Mmamosheledi Elsie
- Subject
- Diabetes
- Subject
- Hyperglycemia
- Subject
- Quinolone antibacterial agents
- Subject
- Cardiovascular system Diseases
- Subject
- Diabetes Alternative treatment
- Subject
- In vitro experiment
- Date
- 2023-03-29
- Type
- Academic theses
- Type
- Master's theses
- Type
- text
- Identifier
- http://hdl.handle.net/10962/409813
- Identifier
- vital:70632
- Description
- Diabetes mellitus (DM) is a group of endocrine and metabolic disorders characterised and identified by the presence of hyperglycaemia over a long period and, to an extent, accompanied by hyperlipidaemia. CVD has been reported to be the leading cause of mortality in patients with DM. Several antidiabetic agents are available for managing DM, but these agents are not for curative therapy and present with undesirable side effects. In addition, these agents become less effective as the patient's condition progresses to complete beta-cell failure. Therefore, developing newer antidiabetic agents with minimal undesirable side effects, prolonged efficacy and protection against the development of DM complications are necessary. This study was conducted to identify potential novel antidiabetic agents with cardiovascular-protective activity. The compounds of interest for the study were quinolone derivatives since quinolones have been reported to have an antihyperglycaemic effect.
- Description
- Thesis (MSc) -- Faculty of Pharmacy, 2023
- Format
- computer, online resource, application/pdf, 1 online resource (138 pages), pdf
- Publisher
- Rhodes University, Faculty of Pharmacy
- Language
- English
- Rights
- Ayodele, Omobolanle Opeyemi
- Rights
- Use of this resource is governed by the terms and conditions of the Creative Commons "Attribution-NonCommercial-ShareAlike" License (http://creativecommons.org/licenses/by-nc-sa/2.0/)
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| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | AYODELE-MSC-TR23-32.pdf | 1 MB | Adobe Acrobat PDF | View Details Download |