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Aspects of the bioavailability of topical corticosteroid formulations

- Magnus, Ashley Denis

  • Authors: Magnus, Ashley Denis
  • Date: 2013-02-12
  • Subjects: Adrenocortical hormones -- Therapeutic use , Dermatologic agents , Transdermal medication -- Evaluation , Dermatopharmacology
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:3843 , http://hdl.handle.net/10962/d1009516 , Adrenocortical hormones -- Therapeutic use , Dermatologic agents , Transdermal medication -- Evaluation , Dermatopharmacology
  • Description: Two possible variables of the McKenzie/Stoughton blanching assay, namely amount applied to the test site and occlusion time have been investigated. Subsequently, two topical steroid preparations, Synalar cream (0,025% fluocinolone acetonide) and Betnovate cream (0,1% betamethasone 17-valer ate) were extemporaneously diluted with five and six placebo bases respectively. Taking cognizance of the two possible variables, these diluted preparations were assessed in vivo using a modified version of the McKenzie/Stoughton blanching assay for blanching activity over a 14 month period. It was found that the base E45, which is slightly alkali, had the greatest effect on both preparations. In the case of betamethasone 17-valerate this base c aused the conversion to the less active isomer, betamethasone 21-valerate whereas at the end of the 14 month test period it was found that the Synalar/E45 dilution contained no fluocinolone acetonide. Quantitative analysis of all the diluted preparations by high performance liquid chromatography using a reverse-phase system was performed. The data obtained f r om the systematic stUdies of the effects of varying concentrations and occlusion times were presented at the Eleventh National Congress of the South African Pharmacological Society. , KMBT_363 , Adobe Acrobat 9.53 Paper Capture Plug-in
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Simochromis margaretae, a new species of cichlid fish from Lake Tanganyika

- Axelrod, G S (Glen S.), Harrison, J A (James A.), Rhodes University. J.L.B. Smith Institute of Ichthyology

  • Authors: Axelrod, G S (Glen S.) , Harrison, J A (James A.) , Rhodes University. J.L.B. Smith Institute of Ichthyology
  • Date: 1978-12
  • Subjects: Simochromis margaretae , Simochromis -- Classification , Fishes -- Classification , Fishes -- Tanganyika, Lake
  • Language: English
  • Type: text , book
  • Identifier: http://hdl.handle.net/10962/69825 , vital:29585 , Margaret Smith Library (South African Institute for Aquatic Biodiversity (SAIAB)) Periodicals Margaret Smith Library (South African Institute for Aquatic Biodiversity (SAIAB))
  • Description: Online version of original print edition of the Special Publication of the J.L.B. Smith Institute of Ichthyology; No. 19 , A new cichlid species of the endemic Lake Tanganyikan genus Simochromis is described from four specimens from Kigoma Harbour, illustrated and compared with the other five species of the genus. The new species, S. margaretae, differs from the others in having a greater caudal peduncle depth, longer anal fin spines, and a narrower mouth. The new species further differs from its closest relative, S. marginatus, in having a greater interorbital width, greater postocular head portion, longer mouth, and shorter pectoral fin.
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  • Date Issued: 1978-12

Pavoclinus myae, a new species of clinid fish (Perciformes Blennoidei) from South Africa, with a note on the identity of P. graminis and P. laurentii, and a key to the known species of Pavoclinus

- Christensen, M S (Makkel Skou), Rhodes University. J.L.B. Smith Institute of Ichthyology

  • Authors: Christensen, M S (Makkel Skou) , Rhodes University. J.L.B. Smith Institute of Ichthyology
  • Date: 1978-07
  • Subjects: Pavoclinus -- Identification , Pavoclinus myae -- Classification , Fishes -- Classification , Fishes -- South Africa -- Classification
  • Language: English
  • Type: text , book
  • Identifier: http://hdl.handle.net/10962/69814 , vital:29584 , Margaret Smith Library (South African Institute for Aquatic Biodiversity (SAIAB)) Periodicals Margaret Smith Library (South African Institute for Aquatic Biodiversity (SAIAB))
  • Description: Online version of original print edition of the Special Publication of the J.L.B. Smith Institute of Ichthyology; No. 18 , Pavoclinus myae n.sp. is described from seven specimens collected off the eastern Cape Province, South Africa. The combination of a separate and high anterior section of the dorsal fin, a narrow caudal peduncle, vomerine teeth and fin counts separates P. myae from the eight other members of the genus. The validity of Pavoclinus graminis and P. laurentii was examined and confirmed. New distinguishing features were found, as characters previously used to differentiate these two species were unreliable.
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  • Date Issued: 1978-07

'Kristu 'vukile

- Music festival participants, Hirmer, O., Composer not specified, Dargie, Dave

A contribution to a generic revision of Simochromis and Tropheus (Pisces : Cichlidae) - from Lake Tanganyika, with special reference to the Pharyngeal Apophysis and its taxonomic importance

- Axelrod, Glen S

  • Authors: Axelrod, Glen S
  • Date: 1978
  • Subjects: Cichlids -- Tanganyika, Lake
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:5349 , http://hdl.handle.net/10962/d1007510 , Cichlids -- Tanganyika, Lake
  • Description: The purpose of this thesis is to investigate the taxonomic status of Simochromis and Tropheue. Material for the study wae collected during three visits to Lake Tanganyika in 1976-1977. Tropheus polli G. S . Axelrod 1977, was found and described, and a new species of Simochromis was found and will be described in a forthcoming paper. Nine colour varieties of Tropheus maorii and three colour varieties of Tropheus duboisi were found and described. A diagnosis and description, with colour photographs, is given using morphometries and meristics of the five species of Simochromis and four species of Tropheus. A dissection and cleaning technique tor the pharyngeal apophysis and lower pharyngeal bone is explained, together with a method for the interpretation of relative bone composition of the pharyngeal apophysis. Photographs are included. The dentition is examined, evaluated and figured. Doubt has been cast upon the taxonomic validity of the composition of the pharyngeal apophysis as an indicator of affinity at the sub familial level. This is shown by its seeming lack of functional relationship, apparent arbitrary variation, interspecific variability in Simochromis and Tropheus, and intraspecific variability in S. diagramma and T. duboisi. Thus, the apophysis cannot be considered a reliable cichlid taxonomic characteristic at any level of classification, unless its validity is Substantiated in each instance. Furthermore, it is considered very probable that the Tropheus-Simochromis species complex is a monophyletic assemblage at the genus level, on the basis of similar dentition and mouth form, which is unique in Lake Tanganyika. It is proposed on phyletic grounds that Simochromis and Tropheus be united into the one genus Tropheus, and that Tropheus be divided into the subgenera , Tropheus (Tropheus) and Tropheus (Simochromis), along the lines of its previous division in two separate genera. Characteristics supporting this division include differences in the anal and dorsal fin meristic counts noted in the original descriptions of the genera. In addition, two modifications of the dentition were found during the course of this study which are not mentioned in any previous literature. It is considered probable, that Tropheus (Tropheus) and Tropheus (Simochromis) are monophyletic sister groups within the Tropheus complex. Pseudosimochromis Nelissen 1977 is not considered to be a taxonomically valid genus on either phyletic or gradistic grounds, and is included within Tropheus (Simochromis). The lower pharyngeal bone of T . (S.) diagramma is considered to be plesiomorphic in tooth arrangement, size and shape. A preliminary worKing hypothesis is established on the basis of the conjectures made and other available information which supports the phyletic relationship suggested by Fryer and lIes (1972). An illustration is given.
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  • Date Issued: 1978

A contribution to the petrology of kimberlites

- Kruger, Floris Johan

  • Authors: Kruger, Floris Johan
  • Date: 1978 , 2013-10-17
  • Subjects: Kimberlite -- Africa, Southern , Petrology , Igneous rocks -- Inclusions
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:5024 , http://hdl.handle.net/10962/d1006886 , Kimberlite -- Africa, Southern , Petrology , Igneous rocks -- Inclusions
  • Description: The petrogenetic relationships of the different varieties of kimberlite in the De Beers Mine and Letseng-Ia-terai composite diatremes have been investigated using petrographic and chemical methods. Kimberlites in the Letseng-Ia-terai diatreme were found to be strongly contaminated by crustal material, mainly basalt. A method to correct for the effects of the contamination has been developed and applied to these kimberlites. Using the corrected data, the four kimberlite types in each group appear to be related to each other by crystal/liquid fractionation models. However the two groups cannot be related to each other. The De Beer Mine has two varieties of kimberlite, a monticellite apatite and calcite rich variety which intruded first, and a phlogopite rich type forming a discrete cylindrical body within the earlier kimberlite. These two kimberlites do not appear to be related by any of the fractionation models discussed. An examination of the data from this work and published sources, suggests that kimberlites are derived from below the low velocity zone by small degrees of partial melting involving garnet lherzolite with subordinate phlogopite and carbonate. Diamonds are probably incorporated as xenocrysts in the magma. Upward movement and emplacement of kimberlite appears to have been very rapid. The diatremes were probably eroded and shaped by gas, derived from the kimberlite magma, escaping to surface along weak zones in the earth's crust. Xenoliths of crustal material incorporated in the kimberlite on intrusion have also been studied and various features due to alteration by the magma are described, including the formation of natrolite and cebollite. The latter is a rare mineral that has not been described from kimberlite before. , KMBT_363 , Adobe Acrobat 9.54 Paper Capture Plug-in
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  • Date Issued: 1978

A Modimo o nne o bokwe

- Music workshop participants, Mahlangu, Mike, Dargie, Dave

A Modimo o nne obokwe = Praise the Lord always

- Marima, E, Thipe, A, Thoba, A, Moswe, C, Composer not specified, Dargie, Dave

A taxonomic study of the Genus Lethrinops Regan (Pisces: Cichlidae) from Lake Malawi: part 2

- Eccles, David H, Lewis, Digby S C

  • Authors: Eccles, David H , Lewis, Digby S C
  • Date: 1978
  • Subjects: Lethrinops -- Malawi, Lake -- Classification , Haplochromis -- Malawi, Lake -- Classification
  • Language: English
  • Type: Text
  • Identifier: vital:14989 , http://hdl.handle.net/10962/d1018957 , ISBN 094998096x , Ichthyological Bulletin of the J.L.B. Smith Institute of Ichthyology; No. 37
  • Description: Lethrinops argentea Ahl, L. lethrinus (Gunther) and L. leptodon Regan are re-described and illustrated. An additional new species, L. longipinnis, sharing with the above the possession a steeply sloping, wedge-shaped snout, a slender lower pharyngeal bone and few (9—14) gillrakers is described. The status of L. lunaris Trewavas is discussed. , Rhodes University Libraries (Digitisation)
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  • Date Issued: 1978

Abraham as a covenant mediator

- Mitchell, Gordon Barry

  • Authors: Mitchell, Gordon Barry
  • Date: 1978
  • Subjects: Abraham (Biblical patriarch) , Covenant theology -- Biblical teaching
  • Language: English
  • Type: Thesis , Bachelor , BDiv
  • Identifier: vital:1238 , http://hdl.handle.net/10962/d1007657 , Abraham (Biblical patriarch) , Covenant theology -- Biblical teaching
  • Description: Conclusion: The [Abrahamic] stories reveal a man caught up in the struggle of faith. But the God who took the initiative in establishing the Covenant shows that in spite of first appearances, He is faithful. The stories present various pictures of Abraham as a Covenant Mediator. Because he is in a sense Israel in microcosm it is not strange that he is described in the terms of Israel's most important institutions: prophet, priest, and king. Nevertheless the most significant Sitz im Leben is the family. While he is usually meant to be understood as an individual representing his immediate family, his descendants, and even all nations, at times, because he is the founding ancestor of Israel and therefore Israel in microcosm, he is best understood as a "Corporate Person". He and Israel are to be a source of blessing to the nations.
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  • Date Issued: 1978

Acclamation after the concentration

- The Setswana church music participants, Bernadett. Sister, Dargie, Dave

Advent, third Sunday

- Creative Music Workshop participants, Composer not specified, Dargie, Dave

Agnus Dei

- Music workshop participants, Composer not specified, Dargie, Dave

Agnus Dei

- Church Choir, Kholosi, George, Composer not specified, Dargie, Dave

Agnus Dei

- Group C of the Klerksdorp music workshop participants, Dargie, Dave

Agnus Dei

- Molefe, S.C, Church Choir, Composer Not Specified, Dargie, Dave

Agnus Dei

- Music workshop participants, Composer not specified, Dargie, Dave

Agnus Dei

- Performer not specified, Composer not specified, Dargie, Dave

Agnus Dei

- Church Choir, Molefe, S. C., Theodora, SCA., Sister, Composer not specified, Dargie, Dave

Agnus Dei

- Performer not specified, Composer not specified, Dargie, Dave

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