South Africa's chemical and biological warfare programme 1981-1995
- Authors: Gould, Chandré
- Date: 2006
- Subjects: Basson, Wouter, 1950- Basson, Wouter, 1950 -- Trials, litigation, etc Biological warfare -- South Africa Chemical warfare -- South Africa Trials (Political crimes and offenses) -- South Africa South Africa -- Politics and government -- History
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:2544 , http://hdl.handle.net/10962/d1002396
- Description: In 1981 the apartheid military initiated a chemical and biological warfare (CBW) programme (code-named Project Coast). The programme, terminated in 1993, was aimed at developing novel irritating and incapacitating agents for internal and external use, covert assassination weapons for use against apartheid opponents, and defensive equipment for use by South African Defence Force (SADF) troops in Angola. The CBW programme was driven by a single individual, Dr Wouter Basson, who reported to a military management committee (the Co-ordinating Management Committee) which comprised a select group of high ranking officers. Practical and financial oversight of the programme was weak which allowed both for the abuse of programme funds and for senior military officers to deny knowledge of aspects of the programme. The biological component of Project Coast was conducted in violation of the commitments of the South African government to the Biological and Toxins Weapons Convention (BTWC). While the state’s commitment to the BTWC was one of the factors considered when initiating the programme, it was not a sufficient constraint to prevent the development of the biological weapons programme, but rather influenced its structure such that the programme could avoid national and international detection. Despite efforts to conceal the military front companies where the chemical and biological warfare (CBW) research and development was undertaken, evidence presented in this thesis shows that the United States had sufficient information about the programme to have been aware of its existence. Yet, it was only in 1993, on the eve of the democratic election in South Africa, that any attempt was made by the US administration to pressure the government to terminate the programme. This thesis considers the factors which influenced the decision to develop Project Coast; the structure and nature of the programme; the motivations of scientists to become involved in the programme and remain involved; the use of chemical and biological agents against opponents of the state, and the factors which influenced the termination of the programme on the eve of the first democratic elections in 1994. It also considers the nature and exent of international support, both tacit and overt, for the programme and argues that the failure of Western nations to call for the termination of the programme before the early 1990s was a function of political expediency and indicates a significant weakness in the ability of international agreements to constrain the development of such programmes.
- Full Text:
- Authors: Gould, Chandré
- Date: 2006
- Subjects: Basson, Wouter, 1950- Basson, Wouter, 1950 -- Trials, litigation, etc Biological warfare -- South Africa Chemical warfare -- South Africa Trials (Political crimes and offenses) -- South Africa South Africa -- Politics and government -- History
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:2544 , http://hdl.handle.net/10962/d1002396
- Description: In 1981 the apartheid military initiated a chemical and biological warfare (CBW) programme (code-named Project Coast). The programme, terminated in 1993, was aimed at developing novel irritating and incapacitating agents for internal and external use, covert assassination weapons for use against apartheid opponents, and defensive equipment for use by South African Defence Force (SADF) troops in Angola. The CBW programme was driven by a single individual, Dr Wouter Basson, who reported to a military management committee (the Co-ordinating Management Committee) which comprised a select group of high ranking officers. Practical and financial oversight of the programme was weak which allowed both for the abuse of programme funds and for senior military officers to deny knowledge of aspects of the programme. The biological component of Project Coast was conducted in violation of the commitments of the South African government to the Biological and Toxins Weapons Convention (BTWC). While the state’s commitment to the BTWC was one of the factors considered when initiating the programme, it was not a sufficient constraint to prevent the development of the biological weapons programme, but rather influenced its structure such that the programme could avoid national and international detection. Despite efforts to conceal the military front companies where the chemical and biological warfare (CBW) research and development was undertaken, evidence presented in this thesis shows that the United States had sufficient information about the programme to have been aware of its existence. Yet, it was only in 1993, on the eve of the democratic election in South Africa, that any attempt was made by the US administration to pressure the government to terminate the programme. This thesis considers the factors which influenced the decision to develop Project Coast; the structure and nature of the programme; the motivations of scientists to become involved in the programme and remain involved; the use of chemical and biological agents against opponents of the state, and the factors which influenced the termination of the programme on the eve of the first democratic elections in 1994. It also considers the nature and exent of international support, both tacit and overt, for the programme and argues that the failure of Western nations to call for the termination of the programme before the early 1990s was a function of political expediency and indicates a significant weakness in the ability of international agreements to constrain the development of such programmes.
- Full Text:
Studies of equivalent fuzzy subgroups of finite abelian p-Groups of rank two and their subgroup lattices
- Authors: Ngcibi, Sakhile Leonard
- Date: 2006
- Subjects: Abelian groups Fuzzy sets Finite groups Group theory Polynomials
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:5416 , http://hdl.handle.net/10962/d1005230
- Description: We determine the number and nature of distinct equivalence classes of fuzzy subgroups of finite Abelian p-group G of rank two under a natural equivalence relation on fuzzy subgroups. Our discussions embrace the necessary theory from groups with special emphasis on finite p-groups as a step towards the classification of crisp subgroups as well as maximal chains of subgroups. Unique naming of subgroup generators as discussed in this work facilitates counting of subgroups and chains of subgroups from subgroup lattices of the groups. We cover aspects of fuzzy theory including fuzzy (homo-) isomorphism together with operations on fuzzy subgroups. The equivalence characterization as discussed here is finer than isomorphism. We introduce the theory of keychains with a view towards the enumeration of maximal chains as well as fuzzy subgroups under the equivalence relation mentioned above. We discuss a strategy to develop subgroup lattices of the groups used in the discussion, and give examples for specific cases of prime p and positive integers n,m. We derive formulas for both the number of maximal chains as well as the number of distinct equivalence classes of fuzzy subgroups. The results are in the form of polynomials in p (known in the literature as Hall polynomials) with combinatorial coefficients. Finally we give a brief investigation of the results from a graph-theoretic point of view. We view the subgroup lattices of these groups as simple, connected, symmetric graphs.
- Full Text:
- Authors: Ngcibi, Sakhile Leonard
- Date: 2006
- Subjects: Abelian groups Fuzzy sets Finite groups Group theory Polynomials
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:5416 , http://hdl.handle.net/10962/d1005230
- Description: We determine the number and nature of distinct equivalence classes of fuzzy subgroups of finite Abelian p-group G of rank two under a natural equivalence relation on fuzzy subgroups. Our discussions embrace the necessary theory from groups with special emphasis on finite p-groups as a step towards the classification of crisp subgroups as well as maximal chains of subgroups. Unique naming of subgroup generators as discussed in this work facilitates counting of subgroups and chains of subgroups from subgroup lattices of the groups. We cover aspects of fuzzy theory including fuzzy (homo-) isomorphism together with operations on fuzzy subgroups. The equivalence characterization as discussed here is finer than isomorphism. We introduce the theory of keychains with a view towards the enumeration of maximal chains as well as fuzzy subgroups under the equivalence relation mentioned above. We discuss a strategy to develop subgroup lattices of the groups used in the discussion, and give examples for specific cases of prime p and positive integers n,m. We derive formulas for both the number of maximal chains as well as the number of distinct equivalence classes of fuzzy subgroups. The results are in the form of polynomials in p (known in the literature as Hall polynomials) with combinatorial coefficients. Finally we give a brief investigation of the results from a graph-theoretic point of view. We view the subgroup lattices of these groups as simple, connected, symmetric graphs.
- Full Text:
Teachers as recontextualisers: a case study analysis of outcomes-based assessment policy implementation in two South African schools
- Authors: Wilmot, Pamela Dianne
- Date: 2006
- Subjects: Competency-based education -- South Africa Competency-based education -- South Africa -- Case studies Educational change -- South Africa Teacher participation in curriculum planning -- South Africa Teachers -- Training of -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:1792 , http://hdl.handle.net/10962/d1003677
- Description: The research presented in this thesis is a case study analysis of outcomes-based assessment in Grade 9 Human and Social Sciences of Curriculum 2005 in two South African schools. The research consists of two parts: Phase One, 2002 to 2003, was a qualitative case study, interpretive in orientation and using ethnographic techniques, aimed at understanding teachers’ responses to curriculum policy and the role of a school-based intervention, located within critically reflexive practice, in supporting change. During this phase, I was a co-participant operating from an insider position. During Phase Two, 2004-2005, I withdrew from the schools and took up an outsider position in order to analyse and theorise the case study. The findings of the interpretive review revealed a fascinating process of change, with some unexpected results that I lacked the theoretical and methodological tools to process. With support from critical friends, I realised that a dynamic and social process of knowledge recontextualisation had taken place, and that the research had moved beyond its initial goals. Not wishing to compromise my integrity as a qualitative researcher, I changed direction and made use of Basil Bernstein’s theorising (1990, 1996) to arrive at a suitable vantage point for the analysis. The main contention of this thesis is that the new OBE curriculum framework offers exciting opportunities for teacher participation in curriculum processes. However, if teachers are to maximise these and become agents of change, they need to acquire the rules of recontextualisation and reposition themselves in the recontextualising field. This implies epistemological empowerment, which takes time and mediation but which can be achieved through an approach to teacher professional development located in critically reflexive practice.
- Full Text:
- Authors: Wilmot, Pamela Dianne
- Date: 2006
- Subjects: Competency-based education -- South Africa Competency-based education -- South Africa -- Case studies Educational change -- South Africa Teacher participation in curriculum planning -- South Africa Teachers -- Training of -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:1792 , http://hdl.handle.net/10962/d1003677
- Description: The research presented in this thesis is a case study analysis of outcomes-based assessment in Grade 9 Human and Social Sciences of Curriculum 2005 in two South African schools. The research consists of two parts: Phase One, 2002 to 2003, was a qualitative case study, interpretive in orientation and using ethnographic techniques, aimed at understanding teachers’ responses to curriculum policy and the role of a school-based intervention, located within critically reflexive practice, in supporting change. During this phase, I was a co-participant operating from an insider position. During Phase Two, 2004-2005, I withdrew from the schools and took up an outsider position in order to analyse and theorise the case study. The findings of the interpretive review revealed a fascinating process of change, with some unexpected results that I lacked the theoretical and methodological tools to process. With support from critical friends, I realised that a dynamic and social process of knowledge recontextualisation had taken place, and that the research had moved beyond its initial goals. Not wishing to compromise my integrity as a qualitative researcher, I changed direction and made use of Basil Bernstein’s theorising (1990, 1996) to arrive at a suitable vantage point for the analysis. The main contention of this thesis is that the new OBE curriculum framework offers exciting opportunities for teacher participation in curriculum processes. However, if teachers are to maximise these and become agents of change, they need to acquire the rules of recontextualisation and reposition themselves in the recontextualising field. This implies epistemological empowerment, which takes time and mediation but which can be achieved through an approach to teacher professional development located in critically reflexive practice.
- Full Text:
The development and application of ecological risk assessment in South African water resource management
- Authors: Claassen, Marius
- Date: 2006
- Subjects: Ecological risk assessment -- South Africa Water resources development -- South Africa Water quality management -- South Africa Water-supply -- Management -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:6036 , http://hdl.handle.net/10962/d1006177
- Description: The provision of goods and services by aquatic ecosystems plays an important role in socio-economic development and livelihoods in the southern African region. Water resource management in South Africa developed from an agrarian and pastoral focus up to 1956 to also supporting mining and industrial activities. This led to the introduction of the resource water quality objectives and pollution prevention approaches, which balanced the needs for development and protection. Prior to 1994, access to water resources was limited to riparian property owners and a minority of the population who controlled industrial and mining activities. The establishment of a democratic government amplified the need for accelerated socio-economic development, with equity, efficiency and sustainability being the principles of such development. New approaches were needed, which could achieve these development objectives and secure the resource base for future generations. An overview of the scientific process highlighted a risk based approach as potentially supporting the much needed balance between development and protection. The aims of this thesis is to develop a framework and process for the application of ecological risk assessment to water resource management in South Africa, to use case studies to draft guidelines for ecological risk assessment and to assess the degree to which ecological risk assessment can contribute to effective water resource management in South Africa. The United States Environmental Protection Agency’s guidelines for ecological risk assessment were identified amongst international best practice as meeting the requirements for local application. A framework was drafted for ecological risk assessment in South Africa, with the main phases being to agree on objectives, formulate the analysis plan, analyse information, characterise risk and manage risk. Modifications from the Environmental Protection Agency’s process include the order of activities in the first phase, the explicit testing of hypotheses and clarification of the evaluation of existing data or collection of new data. An industrial effluent case study was used to assess the applicability of the proposed framework. The case study dealt specifically with the assessment of risks posed by current conditions and long term licence conditions. The framework was found to be useful to identify weaknesses in the established monitoring programme and to evaluate lines of evidence to assess the degree to which the stated conditions would have unacceptable consequences. The study highlighted several weaknesses in the suggested framework, of which the most critical is the interpretation of the risk hypothesis as a testable null hypothesis. It became clear that cause-effect relationships should be stated as the risk hypothesis, whereas the assessment should evaluate expressed or expected conditions against a risk profile for a given stressor to benefit fully from the risk assessment approach. Changes to the framework terminology were suggested as well as nested feedback loops to allow for iterative processes where new information becomes available. The proposed guidelines incorporate the learning from the case study application as well as feedback from a peer review process. The guidelines incorporate the suggested actions under each phase as well as notes providing the rationale for each step. Three case study outlines were provided to assist users with the interpretation of the guidelines in different applications. The proposed guidelines are applied in an ecological Reserve determination case study, which specified the ecological water quality requirements. The study found that a risk-based approach was followed in the development of the water resource management policy, but the Reserve determination method is generally hazard based, with site specific modifications of the target values being allowed on a conservative basis. The case study highlighted a lack of readiness of water resource managers to accommodate scientific results expressed as probability distributions in support of management decisions. The thesis is concluded with a discussion of the key learning points of the ecological risk assessment development process. The evaluation highlights the move from stating and testing a null hypothesis to stating the risk hypothesis and evaluating the stated conditions against a risk profile. Several implementation challenges are highlighted, with specific recommendations made for adopting the proposed guidelines.
- Full Text:
- Authors: Claassen, Marius
- Date: 2006
- Subjects: Ecological risk assessment -- South Africa Water resources development -- South Africa Water quality management -- South Africa Water-supply -- Management -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:6036 , http://hdl.handle.net/10962/d1006177
- Description: The provision of goods and services by aquatic ecosystems plays an important role in socio-economic development and livelihoods in the southern African region. Water resource management in South Africa developed from an agrarian and pastoral focus up to 1956 to also supporting mining and industrial activities. This led to the introduction of the resource water quality objectives and pollution prevention approaches, which balanced the needs for development and protection. Prior to 1994, access to water resources was limited to riparian property owners and a minority of the population who controlled industrial and mining activities. The establishment of a democratic government amplified the need for accelerated socio-economic development, with equity, efficiency and sustainability being the principles of such development. New approaches were needed, which could achieve these development objectives and secure the resource base for future generations. An overview of the scientific process highlighted a risk based approach as potentially supporting the much needed balance between development and protection. The aims of this thesis is to develop a framework and process for the application of ecological risk assessment to water resource management in South Africa, to use case studies to draft guidelines for ecological risk assessment and to assess the degree to which ecological risk assessment can contribute to effective water resource management in South Africa. The United States Environmental Protection Agency’s guidelines for ecological risk assessment were identified amongst international best practice as meeting the requirements for local application. A framework was drafted for ecological risk assessment in South Africa, with the main phases being to agree on objectives, formulate the analysis plan, analyse information, characterise risk and manage risk. Modifications from the Environmental Protection Agency’s process include the order of activities in the first phase, the explicit testing of hypotheses and clarification of the evaluation of existing data or collection of new data. An industrial effluent case study was used to assess the applicability of the proposed framework. The case study dealt specifically with the assessment of risks posed by current conditions and long term licence conditions. The framework was found to be useful to identify weaknesses in the established monitoring programme and to evaluate lines of evidence to assess the degree to which the stated conditions would have unacceptable consequences. The study highlighted several weaknesses in the suggested framework, of which the most critical is the interpretation of the risk hypothesis as a testable null hypothesis. It became clear that cause-effect relationships should be stated as the risk hypothesis, whereas the assessment should evaluate expressed or expected conditions against a risk profile for a given stressor to benefit fully from the risk assessment approach. Changes to the framework terminology were suggested as well as nested feedback loops to allow for iterative processes where new information becomes available. The proposed guidelines incorporate the learning from the case study application as well as feedback from a peer review process. The guidelines incorporate the suggested actions under each phase as well as notes providing the rationale for each step. Three case study outlines were provided to assist users with the interpretation of the guidelines in different applications. The proposed guidelines are applied in an ecological Reserve determination case study, which specified the ecological water quality requirements. The study found that a risk-based approach was followed in the development of the water resource management policy, but the Reserve determination method is generally hazard based, with site specific modifications of the target values being allowed on a conservative basis. The case study highlighted a lack of readiness of water resource managers to accommodate scientific results expressed as probability distributions in support of management decisions. The thesis is concluded with a discussion of the key learning points of the ecological risk assessment development process. The evaluation highlights the move from stating and testing a null hypothesis to stating the risk hypothesis and evaluating the stated conditions against a risk profile. Several implementation challenges are highlighted, with specific recommendations made for adopting the proposed guidelines.
- Full Text:
The development and assessment of a generic carbamazepine sustained release dosage form
- Authors: Patel, Fathima
- Date: 2006
- Subjects: Carbamazepine Pharmacokinetics Drugs -- Controlled release Drugs -- Dosage forms Tablets (Medicine) Drugs -- Administration
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3784 , http://hdl.handle.net/10962/d1003262
- Description: Carbamazepine (CBZ) is a first-line drug used for the treatment of partial and tonic-clonic seizures. It is also the drug of choice for use during pregnancy and recommended for the treatment of seizure disorders in children. CBZ possesses the ability to induce metabolism of drugs that are transformed in the liver and has the unique ability to induce its own metabolism by a phenomenon known as ‘auto- induction’, where its biological half-life is significantly reduced during chronic administration. Large doses of CBZ are often prescribed as daily divided doses and this often adversely affects patient compliance, with the result that therapy is ineffective. A sustained-release dosage form containing CBZ is currently marketed as Tegretol® CR and the development of a generic product would provide patients with an equivalent product with a similar dosing frequency, at a reduced cost. Therefore, the development of a polymer-based matrix tablet was undertaken to produce a sustained-release dosage form of CBZ, since these dosage forms are relatively simple and cheap to produce when compared to other, more sophisticated forms of sustained-release technology. Preformulation studies were conducted to assess moisture content of excipients and dosage forms and to identify possible incompatibilities between CBZ and potential formulation excipients. Furthermore, studies were conducted to assess the potential for polymorphic transitions to occur during manufacture. Stability testing was conducted to assess the behaviour of the dosage forms under storage conditions that the product may be exposed to. Dissolution testing was undertaken using USP Apparatus 3, which allowed for a more realistic assessment and prediction of in vivo drug release rates. Samples were analysed using a high performance liquid chromatographic method that was developed and validated for the determination of CBZ. Tablets were manufactured by wet granulation and direct compression techniques, and the resultant drug release profiles were evaluated statistically by means of the f1 and f2 difference and similarity factors. The f2 factor was incorporated as an assessment criterion in the design of an artificial neural network that was used to predict drug release profiles and formulation composition. A direct compression tablet formulation was successfully adapted from a prototype wet granulation matrix formulation and a number of formulation variables were assessed to establish their effect(s) on the dissolution rate profile of CBZ that resulted from testing of the dosage forms. The particle size grade of CBZ was also investigated and it was ascertained that fine particle size grade CBZ showed improved drug release profiles when compared to the coarse grade CBZ which was desirable, since CBZ is a highly water insoluble compound. Furthermore, the impact of the viscosity grade and proportion of rate-controlling polymer, viz., hydroxypropyl methylcellulose was also investigated for its effect on drug release rates. The lower viscosity grade was found to be more appropriate for use with CBZ. The type of anti-frictional agent used in the formulations did not appear to affect drug release from the polymeric matrix tablets, however specific compounds may have an effect on the physical characteristics of the polymeric tablets. The resultant formulations did not display zero-order drug release kinetics and a first-order mathematical model was developed to provide an additional resource for athematical analysis of dissolution profiles. An artificial neural network was designed, developed and applied to predict dissolution rate profiles for formulation. Furthermore, the network was used to predict formulation compositions that would produce drug release profiles comparable to the reference product, Tegretol® CR. The formulation composition predicted by the network to match the dissolution profile of the innovator product was manufactured and tested in vitro. The formulation was further manipulated, empirically, so as to match the in vitro dissolution rate profile of Tegretol® CR, more completely. The test tablets that were produced were tested in two health male volunteers using Tegretol® CR 400mg as the reference product. The batch used for this “proof of concept” biostudy was produced in accordance with cGMP guidelines and the protocol in accordance with ICH guidelines. The test matrix tablets revealed in vivo bioavailability profiles for CBZ, however, bioequivalence between the test and reference product could not be established. It can be concluded that the polymeric matrix CBZ tablets have the potential to be used as a twice-daily dosage form for the treatment of relevant seizure disorders.
- Full Text:
- Authors: Patel, Fathima
- Date: 2006
- Subjects: Carbamazepine Pharmacokinetics Drugs -- Controlled release Drugs -- Dosage forms Tablets (Medicine) Drugs -- Administration
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3784 , http://hdl.handle.net/10962/d1003262
- Description: Carbamazepine (CBZ) is a first-line drug used for the treatment of partial and tonic-clonic seizures. It is also the drug of choice for use during pregnancy and recommended for the treatment of seizure disorders in children. CBZ possesses the ability to induce metabolism of drugs that are transformed in the liver and has the unique ability to induce its own metabolism by a phenomenon known as ‘auto- induction’, where its biological half-life is significantly reduced during chronic administration. Large doses of CBZ are often prescribed as daily divided doses and this often adversely affects patient compliance, with the result that therapy is ineffective. A sustained-release dosage form containing CBZ is currently marketed as Tegretol® CR and the development of a generic product would provide patients with an equivalent product with a similar dosing frequency, at a reduced cost. Therefore, the development of a polymer-based matrix tablet was undertaken to produce a sustained-release dosage form of CBZ, since these dosage forms are relatively simple and cheap to produce when compared to other, more sophisticated forms of sustained-release technology. Preformulation studies were conducted to assess moisture content of excipients and dosage forms and to identify possible incompatibilities between CBZ and potential formulation excipients. Furthermore, studies were conducted to assess the potential for polymorphic transitions to occur during manufacture. Stability testing was conducted to assess the behaviour of the dosage forms under storage conditions that the product may be exposed to. Dissolution testing was undertaken using USP Apparatus 3, which allowed for a more realistic assessment and prediction of in vivo drug release rates. Samples were analysed using a high performance liquid chromatographic method that was developed and validated for the determination of CBZ. Tablets were manufactured by wet granulation and direct compression techniques, and the resultant drug release profiles were evaluated statistically by means of the f1 and f2 difference and similarity factors. The f2 factor was incorporated as an assessment criterion in the design of an artificial neural network that was used to predict drug release profiles and formulation composition. A direct compression tablet formulation was successfully adapted from a prototype wet granulation matrix formulation and a number of formulation variables were assessed to establish their effect(s) on the dissolution rate profile of CBZ that resulted from testing of the dosage forms. The particle size grade of CBZ was also investigated and it was ascertained that fine particle size grade CBZ showed improved drug release profiles when compared to the coarse grade CBZ which was desirable, since CBZ is a highly water insoluble compound. Furthermore, the impact of the viscosity grade and proportion of rate-controlling polymer, viz., hydroxypropyl methylcellulose was also investigated for its effect on drug release rates. The lower viscosity grade was found to be more appropriate for use with CBZ. The type of anti-frictional agent used in the formulations did not appear to affect drug release from the polymeric matrix tablets, however specific compounds may have an effect on the physical characteristics of the polymeric tablets. The resultant formulations did not display zero-order drug release kinetics and a first-order mathematical model was developed to provide an additional resource for athematical analysis of dissolution profiles. An artificial neural network was designed, developed and applied to predict dissolution rate profiles for formulation. Furthermore, the network was used to predict formulation compositions that would produce drug release profiles comparable to the reference product, Tegretol® CR. The formulation composition predicted by the network to match the dissolution profile of the innovator product was manufactured and tested in vitro. The formulation was further manipulated, empirically, so as to match the in vitro dissolution rate profile of Tegretol® CR, more completely. The test tablets that were produced were tested in two health male volunteers using Tegretol® CR 400mg as the reference product. The batch used for this “proof of concept” biostudy was produced in accordance with cGMP guidelines and the protocol in accordance with ICH guidelines. The test matrix tablets revealed in vivo bioavailability profiles for CBZ, however, bioequivalence between the test and reference product could not be established. It can be concluded that the polymeric matrix CBZ tablets have the potential to be used as a twice-daily dosage form for the treatment of relevant seizure disorders.
- Full Text:
The economic valuation of cultural events in developing countries: combining market and non-market valuation techniques at the South African National Arts Festival
- Authors: Snowball, Jeanette Dalziel
- Date: 2006
- Subjects: Standard Bank National Arts Festival -- Economic aspects , Performing arts festivals -- Economic aspects -- South Africa -- Grahamstown , Arts -- South Africa -- Economic aspects , Finance -- South Africa , Arts -- South Africa -- Finance , Arts -- South Africa -- Political aspects , Finance, Public -- South Africa , South Africa -- Politics and government -- 1994-
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:969 , http://hdl.handle.net/10962/d1002703 , Standard Bank National Arts Festival -- Economic aspects , Performing arts festivals -- Economic aspects -- South Africa -- Grahamstown , Arts -- South Africa -- Economic aspects , Finance -- South Africa , Arts -- South Africa -- Finance , Arts -- South Africa -- Political aspects , Finance, Public -- South Africa , South Africa -- Politics and government -- 1994-
- Description: The arts in many countries, but particularly in developing ones, are coming under increasing financial pressure and finding it difficult to justify the increases in government funding needed to maintain and grow the cultural sector. The trend in cultural economics, as well as in other areas, appears to be towards including qualitative valuations, as well as the more traditional quantitative ones. This thesis argues that the value of cultural events should include long term historical qualitative analysis, financial or economic impact and a valuation of the positive externalities provided by cultural events and that any one of these should only be regarded as a partial analysis. Four methods of valuing the arts using the South African National Arts Festival (NAF) as an example are demonstrated. Firstly, a qualitative historical analysis of the role of the NAF in South Africa’s transformation process from Apartheid to the democratic New South Africa is examined, using theories of cultural capital as a theoretical basis. It is argued that the value of cultural events needs to take into account long-term influences especially in countries undergoing political and social transformation. The second valuation method applied is the traditional economic impact study. Four economic impact studies conducted on the NAF are discussed and methodologies compared. It is concluded that, despite the skepticism of many cultural economists, the method can provide a useful partial valuation and may also be used for effective lobbying for government support of the arts. Chapter four discusses willingness to pay studies conducted at the NAF in 2000 and 2003 (as well as a pilot study conducted at the Klein Karoo Nationale Kunstefees). It is found that lower income and education groups do benefit from the positive externalities provided by the Festival and that this is reflected in their willingness to pay to support it. It is also argued that such contingent valuation studies can provide a reasonably reliable valuation of Festival externalities, but that they may be partly capturing current or future expected financial gains as well. Finally, the relatively new choice experiment methodology (also called conjoint analysis) is demonstrated on visitors to the NAF. The great advantage of this method in valuing cultural events is that it provides part-worths of various Festival attributes for different demographic groups. This enables organizes to structure the programme in such a way as to attract previously excluded groups and to conduct a cost-benefit analysis for each part of the Festival.
- Full Text:
- Authors: Snowball, Jeanette Dalziel
- Date: 2006
- Subjects: Standard Bank National Arts Festival -- Economic aspects , Performing arts festivals -- Economic aspects -- South Africa -- Grahamstown , Arts -- South Africa -- Economic aspects , Finance -- South Africa , Arts -- South Africa -- Finance , Arts -- South Africa -- Political aspects , Finance, Public -- South Africa , South Africa -- Politics and government -- 1994-
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:969 , http://hdl.handle.net/10962/d1002703 , Standard Bank National Arts Festival -- Economic aspects , Performing arts festivals -- Economic aspects -- South Africa -- Grahamstown , Arts -- South Africa -- Economic aspects , Finance -- South Africa , Arts -- South Africa -- Finance , Arts -- South Africa -- Political aspects , Finance, Public -- South Africa , South Africa -- Politics and government -- 1994-
- Description: The arts in many countries, but particularly in developing ones, are coming under increasing financial pressure and finding it difficult to justify the increases in government funding needed to maintain and grow the cultural sector. The trend in cultural economics, as well as in other areas, appears to be towards including qualitative valuations, as well as the more traditional quantitative ones. This thesis argues that the value of cultural events should include long term historical qualitative analysis, financial or economic impact and a valuation of the positive externalities provided by cultural events and that any one of these should only be regarded as a partial analysis. Four methods of valuing the arts using the South African National Arts Festival (NAF) as an example are demonstrated. Firstly, a qualitative historical analysis of the role of the NAF in South Africa’s transformation process from Apartheid to the democratic New South Africa is examined, using theories of cultural capital as a theoretical basis. It is argued that the value of cultural events needs to take into account long-term influences especially in countries undergoing political and social transformation. The second valuation method applied is the traditional economic impact study. Four economic impact studies conducted on the NAF are discussed and methodologies compared. It is concluded that, despite the skepticism of many cultural economists, the method can provide a useful partial valuation and may also be used for effective lobbying for government support of the arts. Chapter four discusses willingness to pay studies conducted at the NAF in 2000 and 2003 (as well as a pilot study conducted at the Klein Karoo Nationale Kunstefees). It is found that lower income and education groups do benefit from the positive externalities provided by the Festival and that this is reflected in their willingness to pay to support it. It is also argued that such contingent valuation studies can provide a reasonably reliable valuation of Festival externalities, but that they may be partly capturing current or future expected financial gains as well. Finally, the relatively new choice experiment methodology (also called conjoint analysis) is demonstrated on visitors to the NAF. The great advantage of this method in valuing cultural events is that it provides part-worths of various Festival attributes for different demographic groups. This enables organizes to structure the programme in such a way as to attract previously excluded groups and to conduct a cost-benefit analysis for each part of the Festival.
- Full Text:
The investigation, development and characterisation of novel zirconium-based tanning agents
- Guthrie-Strachan, Jeffry James
- Authors: Guthrie-Strachan, Jeffry James
- Date: 2006
- Subjects: Zirconium Tanning Leather
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4319 , http://hdl.handle.net/10962/d1004977
- Description: Various oxygen- and nitrogen-donor ligands were investigated as potential zirconium masking agents in zirconium tanning. α-Hydroxycarboxylic acid ligands were identified as effective zirconium(IV) chelators in acidic aqueous solution. Glycolic acid, lactic acid, mandelic acid, 4-hydroxymandelic acid, 4-chloromandelic acid and 4-bromomandelic acid complexes were synthesised, isolated and characterised using a range of analytical techniques. Linear Free Energy Relationships were examined to optimise the stability of the zirconium complexes. Hammett [sigma] plots and Yukawa-Tsuno modified σ plots of the mandelate ligand and zirconium complex series indicated that inductive effects dominate within the benzene ring, however, mesomeric effects are significant outside the ring. Zirconium 4-hydroxymandelate complex solutions were identified as the most effective tanning agents and achieved shrinkage temperatures of 80 and 97ºC for hide powder and goatskin, respectively. The zirconium and 4-hydroxymandelic acid interact synergistically to yield leather equivalent to combination tanned leather in one step. Tanning was performed similarly to vegetable tanning processes with a pickle pH of approximately 5 and fixation was achieved upon acidification. Pilot-scale tanning of goatskin produced white tanned leathers and crust leathers which were physically and aesthetically comparable to matched chromium tanned material.
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- Authors: Guthrie-Strachan, Jeffry James
- Date: 2006
- Subjects: Zirconium Tanning Leather
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4319 , http://hdl.handle.net/10962/d1004977
- Description: Various oxygen- and nitrogen-donor ligands were investigated as potential zirconium masking agents in zirconium tanning. α-Hydroxycarboxylic acid ligands were identified as effective zirconium(IV) chelators in acidic aqueous solution. Glycolic acid, lactic acid, mandelic acid, 4-hydroxymandelic acid, 4-chloromandelic acid and 4-bromomandelic acid complexes were synthesised, isolated and characterised using a range of analytical techniques. Linear Free Energy Relationships were examined to optimise the stability of the zirconium complexes. Hammett [sigma] plots and Yukawa-Tsuno modified σ plots of the mandelate ligand and zirconium complex series indicated that inductive effects dominate within the benzene ring, however, mesomeric effects are significant outside the ring. Zirconium 4-hydroxymandelate complex solutions were identified as the most effective tanning agents and achieved shrinkage temperatures of 80 and 97ºC for hide powder and goatskin, respectively. The zirconium and 4-hydroxymandelic acid interact synergistically to yield leather equivalent to combination tanned leather in one step. Tanning was performed similarly to vegetable tanning processes with a pickle pH of approximately 5 and fixation was achieved upon acidification. Pilot-scale tanning of goatskin produced white tanned leathers and crust leathers which were physically and aesthetically comparable to matched chromium tanned material.
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The poetry of N.H. Brettell : a critical edition
- Authors: Hacksley, Reginald Gregory
- Date: 2006
- Subjects: Brettell, N H -- Criticism and interpretation South African poetry (English) -- History and criticism
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:2289 , http://hdl.handle.net/10962/d1008072
- Description: This thesis presents for the first time a critical reading edition of all known poems by N. H. Brettell. It makes no claim to being definitive, nor does it attempt to establish a final text. It represents merely the best thinking of the editor. Brettell printed and circulated his poetry primarily in hand-made illustrated volumes in a process reminiscent of the scribal publication of the seventeenth century. Only 137 of his 206 extant poems were commercially published during his lifetime. In this study all known printed versions of Brettell's poetry whether in privately printed or commercially published form were examined. All variant readings were recorded and are shown. Wherever possible the relationships between texts are also noted. The poems in this edition are ordered in each case according to the version in the latest datable privately produced collection. The commentary and critical introduction were compiled with the general reader in mind. No previous familiarity with southern African fauna and flora is assumed: animals, birds and insects are described and their scientific names supplied. Expressions current in ordinary British or South African English and present in non-specialist dictionaries are not glossed, but archaic and dialectal forms felt to require explication are briefly explained. So too are less familiar South African dialectal expressions which have been assimilated into the South African English lexicon. Intertextual, Christian and mythological references, both African and Western, are annotated in an attempt to make such references accessible to readers who may not share Brettell's cultural background. The intention is to close the changing distance between the text and the audience. An essay discussing the merits, potential and limitations of electronic scholarly editing is included as part of the textual introduction. A CD-Rom containing Brettell's watercolour illustrations in his privately produced collections and audio-clips of him reading his poetry accompanies this thesis.
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- Authors: Hacksley, Reginald Gregory
- Date: 2006
- Subjects: Brettell, N H -- Criticism and interpretation South African poetry (English) -- History and criticism
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:2289 , http://hdl.handle.net/10962/d1008072
- Description: This thesis presents for the first time a critical reading edition of all known poems by N. H. Brettell. It makes no claim to being definitive, nor does it attempt to establish a final text. It represents merely the best thinking of the editor. Brettell printed and circulated his poetry primarily in hand-made illustrated volumes in a process reminiscent of the scribal publication of the seventeenth century. Only 137 of his 206 extant poems were commercially published during his lifetime. In this study all known printed versions of Brettell's poetry whether in privately printed or commercially published form were examined. All variant readings were recorded and are shown. Wherever possible the relationships between texts are also noted. The poems in this edition are ordered in each case according to the version in the latest datable privately produced collection. The commentary and critical introduction were compiled with the general reader in mind. No previous familiarity with southern African fauna and flora is assumed: animals, birds and insects are described and their scientific names supplied. Expressions current in ordinary British or South African English and present in non-specialist dictionaries are not glossed, but archaic and dialectal forms felt to require explication are briefly explained. So too are less familiar South African dialectal expressions which have been assimilated into the South African English lexicon. Intertextual, Christian and mythological references, both African and Western, are annotated in an attempt to make such references accessible to readers who may not share Brettell's cultural background. The intention is to close the changing distance between the text and the audience. An essay discussing the merits, potential and limitations of electronic scholarly editing is included as part of the textual introduction. A CD-Rom containing Brettell's watercolour illustrations in his privately produced collections and audio-clips of him reading his poetry accompanies this thesis.
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The politics of transformation in South Africa: an evaluation of education policies and their implementation with particular reference to the Eastern Cape Province
- Authors: Rembe, Symphorosa Wilibald
- Date: 2006
- Subjects: Educational change -- South Africa -- Eastern Cape Education -- Political aspects -- South Africa -- Eastern Cape Education and state -- South Africa -- Eastern Cape Post-apartheid era -- South Africa South Africa -- Politics and government -- 1994-
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:2826 , http://hdl.handle.net/10962/d1003036
- Description: The post-apartheid government of South Africa has committed itself to achieving fundamental transformation of the education system. The government has adopted policies and measures that aimed to bring about the goals of equity and redress, and to enhance democracy and participation of all groups in development and decision making processes at all levels. It is acknowledged that the democratic government has accomplished a lot in education within this short period and has made numerous strides in enhancing equity, redress and social justice; providing high quality education for all the people of South Africa; bringing about democratisation and development; and enhancing effectiveness and efficiency. However, despite these apparent achievements, this study shows that there have been a number of setbacks and contradictions in the policies which have affected the process of bringing about fundamental changes and transformation in the education sector. The setbacks and contradictions resulted from factors which have affected the type of policies developed to transform the education sector. They also affected the formulation and implementation of the policies, thereby limiting the achievements of the goals of transformation agenda in education. Hence, this study examined the politics of transformation and change in the education sector by examining the type of policies that have been put in place; their formulation, implementation and outcome. The main research questions are: • What kind or type of policies have been put in place to transform the education sector? • How and by whom were the policies formulated? • How are these policies being implemented and what have been the outcomes of the process? Transformation and in particular the policy process is beset with continuous debate, contestation and struggle for the success of ideas and interests which are pursued by individual actors, groups and policy networks through the institutions. During these different stages policies are modified, constituted and reconstituted. As a result, they give rise to intended and unintended outcomes which are likely to support or contradict the objectives of those policies. Hence, the process cannot be explained using only one approach or theory. Therefore, this study has been situated in ideas, group and network and institutional approaches or theories to examine the factors that have affected education policies, their formulation and implementation and the overall transformation of education in South Africa. It contends that policy change and variation result from interaction of ideas and interests within patterns of group and policy networks and preset institutions. The study adopts qualitative interpretive methodology in order to question, understand and explain institutions; interests groups and ideas; socio economic and power relations involved in the process. It also appraises the framework for action. In addition to conducting literature review, unstructured interviews were held with officials from provincial and national Departments of Education, members of national and provincial legislatures, principals, teachers, members of school governing bodies, learners, Non-governmental organisations, Community based organisations, Faith based organisations, teachers’ and workers’ unions. Observations were made during meetings of school governing bodies. The study draws reference from the Eastern Cape Province between 1994 and 2002 and looks at the school level (Basic and Further Education levels). Reference is also made to selective policy instruments namely, the South African Schools Act (SASA) (1996), Curriculum 2005 and Norms and Standards for School Funding (1999). Overall, the findings of the study have shown that various factors have led to setbacks and contradictions in the policies that were adopted in education. They have also affected the formulation and implementation of the policies, hence exerting certain limitations on the achievements of the goals of transformation in education. The factors identified in the findings are the outcome of the negotiated settlement and subsequent changes made by the apartheid government in education before the 1994 elections; constraints and unequal participation of different groups in education policy development in various established structures and avenues; drawbacks in the implementation of education policies by decentralised structures and agents at various levels. This was exacerbated by lack of capacity, lack of adequate resources, lack of commitment and will among some of the civil servants coupled with corruption and mismanagement. The legacy of apartheid and the homeland governments, together with existing backlogs added another layer. Consequently, there were challenges in the economic policy which led to inadequate funding for education. The findings of this study show that competing ideas and interests advanced by groups and networks have impact on decision making, policy content and implementation. Therefore, some policies will reflect and maintain the interests of those individual actors, groups and policy networks that exerted most influence. The findings also reveal that institutional norms and rules, inadequate resources, lack of capacity and skilled human resources and economic environment, constrain decision making, policy content and implementation.
- Full Text:
- Authors: Rembe, Symphorosa Wilibald
- Date: 2006
- Subjects: Educational change -- South Africa -- Eastern Cape Education -- Political aspects -- South Africa -- Eastern Cape Education and state -- South Africa -- Eastern Cape Post-apartheid era -- South Africa South Africa -- Politics and government -- 1994-
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:2826 , http://hdl.handle.net/10962/d1003036
- Description: The post-apartheid government of South Africa has committed itself to achieving fundamental transformation of the education system. The government has adopted policies and measures that aimed to bring about the goals of equity and redress, and to enhance democracy and participation of all groups in development and decision making processes at all levels. It is acknowledged that the democratic government has accomplished a lot in education within this short period and has made numerous strides in enhancing equity, redress and social justice; providing high quality education for all the people of South Africa; bringing about democratisation and development; and enhancing effectiveness and efficiency. However, despite these apparent achievements, this study shows that there have been a number of setbacks and contradictions in the policies which have affected the process of bringing about fundamental changes and transformation in the education sector. The setbacks and contradictions resulted from factors which have affected the type of policies developed to transform the education sector. They also affected the formulation and implementation of the policies, thereby limiting the achievements of the goals of transformation agenda in education. Hence, this study examined the politics of transformation and change in the education sector by examining the type of policies that have been put in place; their formulation, implementation and outcome. The main research questions are: • What kind or type of policies have been put in place to transform the education sector? • How and by whom were the policies formulated? • How are these policies being implemented and what have been the outcomes of the process? Transformation and in particular the policy process is beset with continuous debate, contestation and struggle for the success of ideas and interests which are pursued by individual actors, groups and policy networks through the institutions. During these different stages policies are modified, constituted and reconstituted. As a result, they give rise to intended and unintended outcomes which are likely to support or contradict the objectives of those policies. Hence, the process cannot be explained using only one approach or theory. Therefore, this study has been situated in ideas, group and network and institutional approaches or theories to examine the factors that have affected education policies, their formulation and implementation and the overall transformation of education in South Africa. It contends that policy change and variation result from interaction of ideas and interests within patterns of group and policy networks and preset institutions. The study adopts qualitative interpretive methodology in order to question, understand and explain institutions; interests groups and ideas; socio economic and power relations involved in the process. It also appraises the framework for action. In addition to conducting literature review, unstructured interviews were held with officials from provincial and national Departments of Education, members of national and provincial legislatures, principals, teachers, members of school governing bodies, learners, Non-governmental organisations, Community based organisations, Faith based organisations, teachers’ and workers’ unions. Observations were made during meetings of school governing bodies. The study draws reference from the Eastern Cape Province between 1994 and 2002 and looks at the school level (Basic and Further Education levels). Reference is also made to selective policy instruments namely, the South African Schools Act (SASA) (1996), Curriculum 2005 and Norms and Standards for School Funding (1999). Overall, the findings of the study have shown that various factors have led to setbacks and contradictions in the policies that were adopted in education. They have also affected the formulation and implementation of the policies, hence exerting certain limitations on the achievements of the goals of transformation in education. The factors identified in the findings are the outcome of the negotiated settlement and subsequent changes made by the apartheid government in education before the 1994 elections; constraints and unequal participation of different groups in education policy development in various established structures and avenues; drawbacks in the implementation of education policies by decentralised structures and agents at various levels. This was exacerbated by lack of capacity, lack of adequate resources, lack of commitment and will among some of the civil servants coupled with corruption and mismanagement. The legacy of apartheid and the homeland governments, together with existing backlogs added another layer. Consequently, there were challenges in the economic policy which led to inadequate funding for education. The findings of this study show that competing ideas and interests advanced by groups and networks have impact on decision making, policy content and implementation. Therefore, some policies will reflect and maintain the interests of those individual actors, groups and policy networks that exerted most influence. The findings also reveal that institutional norms and rules, inadequate resources, lack of capacity and skilled human resources and economic environment, constrain decision making, policy content and implementation.
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The significance of the local trade in natural resource products for livelihoods and poverty alleviation in South Africa
- Authors: Shackleton, Sheona E
- Date: 2006
- Subjects: Poverty -- South Africa Rural poor -- South Africa Natural resources -- South Africa Selling -- Handicraft South Africa -- Commerce
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4776 , http://hdl.handle.net/10962/d1011731
- Description: What role can the commercialisation of natural resource products play in the efforts to reduce poverty and vulnerability and how can this be enhanced? With poverty alleviation at the top of the global development agenda, this is a question posed by many scholars, practitioners, donor agencies and government departments operating at the environment-development interface. However, recent commentary on this issue is mixed and ambiguous, with some observers being quite optimistic regarding the potential of these products, while others hold a counter view. This thesis explores the livelihood contributions and poverty alleviation potential of four products traded locally in the Bushbuckridge municipality, South Africa; namely traditional brooms, reed mats, woodcraft and a beer made from the fruits of Sclerocarya birrea. A common approach, employing both quantitative and qualitative methods, was used to investigate the harvesting, processing and marketing arrangements, sustainability and livelihood contributions of each product. The results illustrate that any inference regarding the potential of the trade to alleviate poverty depends on how poverty is defined and interpreted, and on whether the role of these products is assessed from a holistic livelihood perspective that includes notions of vulnerability, alternatives and choice, diversification and the needs of rural producers themselves. Overall, the products studied were key in enhancing the livelihood security of the poorest members of society, forming an important safety net and assisting in raising household incomes to levels equivalent to the wider population, but generally were unlikely, on their own, to provide a route out of poverty. However, there were notable exceptions, with marked variation evident both within and across products. Incomes often surpassed local wage rates, and a minority of producers were obtaining returns equivalent to or greater than the official minimum wage. Other benefits, such as the opportunity to work from home or to diversify the livelihood portfolio, were also crucial, with the trade representing different livelihood strategies for different households. When viewed within the context of rising unemployment and HIV/AIDS these findings assume greater significance. While the trades were complex and growth limited, livelihood benefits could be improved on a sustainable basis if the sector was given the attention and support it deserves.
- Full Text:
- Authors: Shackleton, Sheona E
- Date: 2006
- Subjects: Poverty -- South Africa Rural poor -- South Africa Natural resources -- South Africa Selling -- Handicraft South Africa -- Commerce
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4776 , http://hdl.handle.net/10962/d1011731
- Description: What role can the commercialisation of natural resource products play in the efforts to reduce poverty and vulnerability and how can this be enhanced? With poverty alleviation at the top of the global development agenda, this is a question posed by many scholars, practitioners, donor agencies and government departments operating at the environment-development interface. However, recent commentary on this issue is mixed and ambiguous, with some observers being quite optimistic regarding the potential of these products, while others hold a counter view. This thesis explores the livelihood contributions and poverty alleviation potential of four products traded locally in the Bushbuckridge municipality, South Africa; namely traditional brooms, reed mats, woodcraft and a beer made from the fruits of Sclerocarya birrea. A common approach, employing both quantitative and qualitative methods, was used to investigate the harvesting, processing and marketing arrangements, sustainability and livelihood contributions of each product. The results illustrate that any inference regarding the potential of the trade to alleviate poverty depends on how poverty is defined and interpreted, and on whether the role of these products is assessed from a holistic livelihood perspective that includes notions of vulnerability, alternatives and choice, diversification and the needs of rural producers themselves. Overall, the products studied were key in enhancing the livelihood security of the poorest members of society, forming an important safety net and assisting in raising household incomes to levels equivalent to the wider population, but generally were unlikely, on their own, to provide a route out of poverty. However, there were notable exceptions, with marked variation evident both within and across products. Incomes often surpassed local wage rates, and a minority of producers were obtaining returns equivalent to or greater than the official minimum wage. Other benefits, such as the opportunity to work from home or to diversify the livelihood portfolio, were also crucial, with the trade representing different livelihood strategies for different households. When viewed within the context of rising unemployment and HIV/AIDS these findings assume greater significance. While the trades were complex and growth limited, livelihood benefits could be improved on a sustainable basis if the sector was given the attention and support it deserves.
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Using experiential learning to facilitate pharmacy students' understanding of patients' medication practice in chronic illness
- Authors: Williams, Kevin F
- Date: 2006
- Subjects: Chronic diseases -- Chemotherapy Chronically ill -- Care Pharmacy -- Study and teaching Pharmacy -- Practice Social medicine Health -- Sociological aspects Diseases -- Sociological aspects Health -- Psychological aspects
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:1322 , http://hdl.handle.net/10962/d1003955
- Description: This study originates from experiences which led me to question the way pharmacists are equipped to advise and support the medicine-taking practice of patients using chronic medication. The study offers a critical theoretical consideration of underlying perspectives informing pharmacy education. I propose following a critical realist ontological perspective, a social realist understanding of social structure and human agency, and a sociocultural epistemology. Based on these perspectives, I consider a sociological critique of ‘health’, ‘disease’, ‘illness’ and ‘sickness’ perspectives on medicine-taking, and of pharmacy as a profession. I then propose an experiential learning approach, with an emphasis on developing reflexivity through affective learning. I follow this with an illustrative case study. Following a critical discourse analysis of student texts from the case study, I conclude that there is evidence that experiential learning may prove useful in developing pharmacy students’ reflexive competency to support the provision of pharmaceutical care to patients using chronic medications.
- Full Text:
- Authors: Williams, Kevin F
- Date: 2006
- Subjects: Chronic diseases -- Chemotherapy Chronically ill -- Care Pharmacy -- Study and teaching Pharmacy -- Practice Social medicine Health -- Sociological aspects Diseases -- Sociological aspects Health -- Psychological aspects
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:1322 , http://hdl.handle.net/10962/d1003955
- Description: This study originates from experiences which led me to question the way pharmacists are equipped to advise and support the medicine-taking practice of patients using chronic medication. The study offers a critical theoretical consideration of underlying perspectives informing pharmacy education. I propose following a critical realist ontological perspective, a social realist understanding of social structure and human agency, and a sociocultural epistemology. Based on these perspectives, I consider a sociological critique of ‘health’, ‘disease’, ‘illness’ and ‘sickness’ perspectives on medicine-taking, and of pharmacy as a profession. I then propose an experiential learning approach, with an emphasis on developing reflexivity through affective learning. I follow this with an illustrative case study. Following a critical discourse analysis of student texts from the case study, I conclude that there is evidence that experiential learning may prove useful in developing pharmacy students’ reflexive competency to support the provision of pharmaceutical care to patients using chronic medications.
- Full Text: