- Title
- Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells:
- Creator
- Hunter, Morgan C, O’Hagan, Kyle L, Kenyon, Amy, Dhanani, Karim C H, Prinsloo, Earl, Edkins, Adrienne L
- Date
- 2014
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/164841
- Identifier
- vital:41177
- Identifier
- DOI: 10.1371/journal.pone.0086842
- Description
- Heat shock protein 90 (Hsp90) has been identified in the extracellular space and has been shown to chaperone a finite number of extracellular proteins involved in cell migration and invasion. We used chemical cross-linking and immunoprecipitation followed by tandem mass spectrometry (MS/MS) to isolate a complex containing Hsp90 and the matrix protein fibronectin (FN) from breast cancer cells.
- Format
- 18 pages, pdf
- Language
- English
- Relation
- PloS one, Hunter, M.C., O’Hagan, K.L., Kenyon, A., Dhanani, K.C., Prinsloo, E. and Edkins, A.L., 2014. Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells. PloS one, 9(1), p.e86842, PloS one volume 9 number 1 1 17 January 2014 1932-6203
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the PLOSOne Terms of Use Statement (https://www.plos.org/terms-of-use )
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